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[缺血性卒中的溶栓警报:非斯国际私立诊所阿尔巴迪的经验(60例横断面研究)]

[Thrombolysis alert in ischemic stroke: experience of the international private clinic Al Badie in Fez (cross-sectional study of 60 cases)].

作者信息

Najmi Imane, Idrissi Saber Janati, Bensouda Khadija, Marzouki Zineb, Dinia Mohammed, Talbi Ilyass, Benmaamar Soumaya, Bouchal Siham, El Fakir Samira, El Rhazi Karima, Fihri Oussama Fassi, Belahsen Mohammed Faouzi

机构信息

Unité Neurovasculaire, Clinique Internationale Al Badie, 355 Lotissement Jardins El Badie, Ain Chkf, 30000 Fès, Maroc.

Service des Urgences, Clinique Internationale Al Badie, Fès, Maroc.

出版信息

Pan Afr Med J. 2024 Apr 4;47:167. doi: 10.11604/pamj.2024.47.167.42376. eCollection 2024.

DOI:10.11604/pamj.2024.47.167.42376
PMID:39036032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260060/
Abstract

Intravenous thrombolysis is the standard treatment for acute ischemic stroke. We here report the cases of thrombolysis alert in the private sector in Morocco We conducted a prospective study of all patients with neurological deficit of sudden onset occurred within the first 12 hours admitted to the Emergency Department of the Al Badie international private clinic from January 2022 to September 2023. Epidemiological, clinical and etiological characteristics as well as data on outpatient and inpatient delays were collected. Sixty patients were included in the study. The average admission delay was 198.36 ± 79.23 minutes. The mean NIHSS (National Institutes of Health Stroke Scale) score was 10.41 ± 4.97. The average time for imaging was 26.68 ± 9.63 minutes. Ischaemic stroke was the most common diagnosis (85%), followed by "stroke mimics" (11.6%). Thirteen patients underwent thrombolysis with tenecteplase. The mean time from admission to the initiation of thrombolysis was 107.15 ± 24.48 minutes. Follow-up imaging at 24 hours post thrombolysis revealed symptomatic haemorrhagic transformation in 3 patients. Six patients were transferred to the Hassan II University Hospital for thrombolysis and/or mechanical thrombectomy. After 3 months, 4 patients were autonomous (Rankin score changed between 0 and 2). Our experience shows that it is imperative to reduce outpatient and inpatient delays in treatment in order to increase the proportion of patients treated with thrombolysis.

摘要

静脉溶栓是急性缺血性卒中的标准治疗方法。我们在此报告摩洛哥私立部门溶栓警报的病例。我们对2022年1月至2023年9月入住阿尔巴迪国际私立诊所急诊科的所有在发病后12小时内突然出现神经功能缺损的患者进行了一项前瞻性研究。收集了流行病学、临床和病因学特征以及门诊和住院延迟的数据。60名患者纳入研究。平均入院延迟为198.36±79.23分钟。美国国立卫生研究院卒中量表(NIHSS)平均评分为10.41±4.97。平均影像学检查时间为26.68±9.63分钟。缺血性卒中是最常见的诊断(85%),其次是“类卒中”(11.6%)。13名患者接受了替奈普酶溶栓治疗。从入院到开始溶栓的平均时间为107.15±24.48分钟。溶栓后24小时的随访影像学检查显示3例患者出现症状性出血转化。6名患者被转至哈桑二世大学医院进行溶栓和/或机械取栓治疗。3个月后,4名患者生活自理(Rankin评分在0至2分之间变化)。我们的经验表明,必须减少门诊和住院治疗延迟,以提高接受溶栓治疗的患者比例。

相似文献

1
[Thrombolysis alert in ischemic stroke: experience of the international private clinic Al Badie in Fez (cross-sectional study of 60 cases)].[缺血性卒中的溶栓警报:非斯国际私立诊所阿尔巴迪的经验(60例横断面研究)]
Pan Afr Med J. 2024 Apr 4;47:167. doi: 10.11604/pamj.2024.47.167.42376. eCollection 2024.
2
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Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital.在摩洛哥一家医院急诊科使用替奈普酶进行急性缺血性卒中溶栓治疗。
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Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset.多模态 MRI 引导下静脉溶栓治疗起病时间不明的脑卒中患者的结局。
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本文引用的文献

1
Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials.替奈普酶与阿替普酶治疗急性缺血性卒中的疗效比较:随机试验的系统评价与荟萃分析
Front Neurol. 2023 Jan 23;14:1102463. doi: 10.3389/fneur.2023.1102463. eCollection 2023.
2
Reasons for Exclusion From Intravenous Thrombolysis in Acute Ischemic Stroke: Experience From a Moroccan Stroke Unit.急性缺血性卒中患者被排除接受静脉溶栓治疗的原因:来自摩洛哥一家卒中单元的经验
Cureus. 2023 Jan 2;15(1):e33248. doi: 10.7759/cureus.33248. eCollection 2023 Jan.
3
Assessment of eligibility for thrombolysis in acute ischaemic stroke patients in Morocco.摩洛哥急性缺血性脑卒中患者溶栓治疗的资格评估。
Pan Afr Med J. 2020 Aug 26;36:351. doi: 10.11604/pamj.2020.36.351.22599. eCollection 2020.
4
Ischemic stroke in Morocco: a systematic review.摩洛哥的缺血性中风:一项系统综述。
BMC Neurol. 2019 Dec 30;19(1):349. doi: 10.1186/s12883-019-1558-1.
5
Stroke in the Middle-East and North Africa: A 2-year prospective observational study of stroke characteristics in the region-Results from the Safe Implementation of Treatments in Stroke (SITS)-Middle-East and North African (MENA).中东和北非地区的脑卒中:该地区脑卒中特征的 2 年前瞻性观察研究-结果来自脑卒中治疗安全实施(SITS)-中东和北非(MENA)。
Int J Stroke. 2019 Oct;14(7):715-722. doi: 10.1177/1747493019830331. Epub 2019 Mar 12.
6
Stroke care in Africa: A systematic review of the literature.非洲的脑卒中护理:文献系统评价。
Int J Stroke. 2018 Oct;13(8):797-805. doi: 10.1177/1747493018772747. Epub 2018 Apr 17.
7
Long-Term Survival After Intravenous Thrombolysis for Ischemic Stroke: A Propensity Score-Matched Cohort With up to 10-Year Follow-Up.缺血性卒中静脉溶栓后的长期生存:一项倾向评分匹配队列研究,随访长达10年
Stroke. 2018 Mar;49(3):607-613. doi: 10.1161/STROKEAHA.117.019889. Epub 2018 Feb 12.
8
Thrombolysis Alert in Hassan II University Teaching Hospital of Fez (Morocco): A Prospective Study of 2 Years.摩洛哥非斯哈桑二世大学教学医院的溶栓警报:一项为期两年的前瞻性研究
J Stroke Cerebrovasc Dis. 2018 Apr;27(4):1100-1106. doi: 10.1016/j.jstrokecerebrovasdis.2017.11.022. Epub 2017 Dec 29.
9
Impact of a direct-admission stroke pathway on delays of admission, care, and rates of intravenous thrombolysis.直接入院卒中路径对入院延迟、治疗延迟及静脉溶栓率的影响。
Rev Neurol (Paris). 2016 Dec;172(12):756-760. doi: 10.1016/j.neurol.2016.10.008. Epub 2016 Nov 17.
10
Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital.在摩洛哥一家医院急诊科使用替奈普酶进行急性缺血性卒中溶栓治疗。
Pan Afr Med J. 2015 May 19;21:37. doi: 10.11604/pamj.2015.21.37.6491. eCollection 2015.