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RAISN:临床I期生殖细胞肿瘤中机器人辅助吲哚菁绿引导的前哨淋巴结活检

RAISN: Robot-assisted Indocyanine Green-guided Sentinel Node Biopsy in Clinical Stage I Germ Cell Tumor.

作者信息

Vermeulen-Spohn Marieke Sofie, Pongratanakul Pailin, Thy Sophia, Dukart Juergen, Albers Peter, Che Yue

机构信息

Department of Urology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Institute of Neurosciences and Medicine, Forschungszentrum Jülich, Jülich, Germany.

出版信息

Eur Urol Open Sci. 2024 Jun 27;66:55-59. doi: 10.1016/j.euros.2024.06.004. eCollection 2024 Aug.

DOI:10.1016/j.euros.2024.06.004
PMID:39036045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260343/
Abstract

Robot-assisted imaging-guided sentinel lymph node biopsy is a novel technique that has not been widely investigated in testicular germ cell tumor (GCT). Current staging strategies have poor accuracy for prediction of occult metastatic disease in clinical stage I GCT. Feasibility studies have used Tc-nanocolloid staining during laparoscopic procedures. The RAISN trial is investigating robot-assisted lymph node resection guided by indocyanine green fluorescence imaging. This new diagnostic approach is potentially more precise and easier to apply, and is widely available. Confirmation of its utility could change the management of newly diagnosed GCT by reducing overtreatment and treatment-related toxicity.

摘要

机器人辅助成像引导下前哨淋巴结活检是一种尚未在睾丸生殖细胞肿瘤(GCT)中得到广泛研究的新技术。目前的分期策略在预测临床I期GCT隐匿性转移疾病方面准确性较差。可行性研究在腹腔镜手术中使用了锝纳米胶体染色。RAISN试验正在研究吲哚菁绿荧光成像引导下的机器人辅助淋巴结切除术。这种新的诊断方法可能更精确且易于应用,并且广泛可用。证实其效用可能会通过减少过度治疗和治疗相关毒性来改变新诊断GCT的管理方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/c49404acec6f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/80f1e70338a5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/d901c867a83a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/c49404acec6f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/80f1e70338a5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/d901c867a83a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fba/11260343/c49404acec6f/gr3.jpg

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本文引用的文献

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Cardiovascular Disease in Testicular Cancer Survivors: Identification of Risk Factors and Impact on Quality of Life.睾丸癌幸存者的心血管疾病:危险因素的识别及其对生活质量的影响。
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European Association for Endoscopic Surgery (EAES) consensus on Indocyanine Green (ICG) fluorescence-guided surgery.
欧洲内镜外科学会(EAES)关于吲哚菁绿(ICG)荧光引导手术的共识。
Surg Endosc. 2023 Mar;37(3):1629-1648. doi: 10.1007/s00464-023-09928-5. Epub 2023 Feb 13.
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Testicular Cancer in the Cisplatin Era: Causes of Death and Mortality Rates in a Population-Based Cohort.顺铂时代的睾丸癌:基于人群的队列研究中的死因和死亡率。
J Clin Oncol. 2021 Nov 10;39(32):3561-3573. doi: 10.1200/JCO.21.00637. Epub 2021 Aug 13.
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Combined use of ICG and technetium does not improve sentinel lymph node detection in endometrial cancer: Results of the COMBITEC study.ICG 与锝联合使用并未提高子宫内膜癌前哨淋巴结检测的准确性:COMBITEC 研究结果。
Gynecol Oncol. 2021 Jul;162(1):32-37. doi: 10.1016/j.ygyno.2021.05.002. Epub 2021 May 13.
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Indocyanine green versus technetium-99m with blue dye for sentinel lymph node detection in early-stage cervical cancer: A systematic review and meta-analysis.吲哚菁绿与锝-99m 联合蓝色染料在早期宫颈癌前哨淋巴结检测中的应用:系统评价和荟萃分析。
Cancer Rep (Hoboken). 2022 Jan;5(1):e1401. doi: 10.1002/cnr2.1401. Epub 2021 May 11.
7
Safety and Efficacy of Indocyanine Green Tracer-Guided Lymph Node Dissection During Laparoscopic Radical Gastrectomy in Patients With Gastric Cancer: A Randomized Clinical Trial.吲哚菁绿示踪剂引导腹腔镜胃癌根治术中淋巴结清扫的安全性和有效性:一项随机临床试验。
JAMA Surg. 2020 Apr 1;155(4):300-311. doi: 10.1001/jamasurg.2019.6033.
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Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease.临床Ⅰ期睾丸癌前哨淋巴结活检可早期发现隐匿性转移疾病。
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Testicular germ cell tumours.睾丸生殖细胞肿瘤。
Lancet. 2016 Apr 23;387(10029):1762-74. doi: 10.1016/S0140-6736(15)00991-5. Epub 2015 Dec 3.