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缺血性中风患者的牙周疾病——一项探索性研究

Periodontal Disease in Patients with Ischemic Stroke - an Exploratory Study.

作者信息

Radujković Vedran, Lovrenčić-Huzjan Arijana, Puhar Ivan

机构信息

PhD student, University of Zagreb School of Dental Medicine, Zagreb, Croatia.

Clinical Department of Neurology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

出版信息

Acta Stomatol Croat. 2024 Jun;58(2):110-122. doi: 10.15644/asc58/2/1.

DOI:10.15644/asc58/2/1
PMID:39036330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11256875/
Abstract

OBJECTIVE

The aim of this study was to assess the periodontal disease parameters in patients with ischemic stroke.

MATERIALS AND METHODS

The study included 21 patients with ischemic brain stroke and a control group that was matched in number, age, and gender. All participants underwent a standard periodontal examination. The inclusion criterion of this study was the presence of at least 15 teeth. Periodontal epithelial surface area, periodontal inflamed surface area (PISA), and periodontal disease stage were determined. All participants were given a questionnaire to determine oral health-related quality of life (OHQL). Stroke risk factors were assessed.

RESULTS

Stroke patients had a significantly higher OHQL score than the control group (20.81 vs. 12.57) and a full-mouth plaque score (FMPS, 27.57 vs. 16.83), while full-mouth bleeding score (FMBS) was significantly higher in the control group than in the hospital group (10.17 vs. 6.42). For PISA, statistically significant negative correlations were found for smoking, cholesterol levels, and LDL levels, while significant positive correlations were found for FMBS, clinical attachment level and probing depth.

CONCLUSION

Although PISA does represent the amount of periodontal tissue that is inflamed, tooth loss due to advanced periodontal disease combined with oral hygiene limitations imposed by the hospital setting and the stroke recovery process remain the most significant obstacles for a more meaningful understanding of the data represented by specific clinical, laboratory and various demographic parameters that characterize the two diseases.

摘要

目的

本研究旨在评估缺血性脑卒中患者的牙周疾病参数。

材料与方法

该研究纳入了21例缺血性脑卒中患者以及一个在数量、年龄和性别上相匹配的对照组。所有参与者均接受了标准的牙周检查。本研究的纳入标准是至少有15颗牙齿。测定了牙周上皮表面积、牙周炎症表面积（PISA）和牙周疾病分期。所有参与者均填写了一份问卷以确定口腔健康相关生活质量（OHQL）。评估了中风危险因素。

结果

中风患者的OHQL评分显著高于对照组（20.81对12.57），全口菌斑评分（FMPS，27.57对16.83），而对照组的全口出血评分（FMBS）显著高于住院组（10.17对6.42）。对于PISA，发现吸烟、胆固醇水平和低密度脂蛋白水平与之存在统计学显著负相关，而FMBS、临床附着水平和探诊深度与之存在显著正相关。

结论

尽管PISA确实代表了发炎的牙周组织量，但由于晚期牙周疾病导致的牙齿缺失，再加上医院环境和中风恢复过程所带来的口腔卫生限制，仍然是更有意义地理解表征这两种疾病的特定临床、实验室和各种人口统计学参数所代表的数据的最大障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/78db4f83b935/ASC_58(2)_110-122-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/7b3a51693ea5/ASC_58(2)_110-122-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/3407a1bb231e/ASC_58(2)_110-122-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/85b914e1649d/ASC_58(2)_110-122-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/78db4f83b935/ASC_58(2)_110-122-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/7b3a51693ea5/ASC_58(2)_110-122-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/3407a1bb231e/ASC_58(2)_110-122-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/85b914e1649d/ASC_58(2)_110-122-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02a/11256875/78db4f83b935/ASC_58(2)_110-122-f4.jpg

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本文引用的文献

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Metagenomic Analysis of Bacterial Microflora in Dental and Atherosclerotic Plaques of Patients With Internal Carotid Artery Stenosis.颈内动脉狭窄患者牙齿和动脉粥样硬化斑块中细菌微生物群的宏基因组分析
Clin Med Insights Cardiol. 2024 Feb 6;18:11795468231225852. doi: 10.1177/11795468231225852. eCollection 2024.
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The association between periodontitis and cerebrovascular disease, and dementia. Scientific report of the working group of the Spanish Society of Periodontology and the Spanish Society of Neurology.牙周炎与脑血管病和痴呆的关系。西班牙牙周病学会和西班牙神经病学学会工作组的科学报告。
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Clinical, oral immunological and microbiological shifts during and after pregnancy.
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Clin Oral Investig. 2023 Dec 29;28(1):60. doi: 10.1007/s00784-023-05408-1.
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The bidirectional association between diabetes and periodontitis, from basic to clinical.糖尿病与牙周炎之间的双向关联：从基础到临床
Jpn Dent Sci Rev. 2024 Dec;60:15-21. doi: 10.1016/j.jdsr.2023.12.002. Epub 2023 Dec 12.
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Periodontal Disease Treatment After Stroke or Transient Ischemic Attack: The PREMIERS Study, a Randomized Clinical Trial.牙周病治疗后的中风或短暂性脑缺血发作：PREMIERS 研究，一项随机临床试验。
Stroke. 2023 Sep;54(9):2214-2222. doi: 10.1161/STROKEAHA.122.042047. Epub 2023 Aug 7.
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Stroke Rehabilitation and Motor Recovery.中风康复与运动恢复
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Breaking the Gingival Barrier in Periodontitis.牙周炎中龈下屏障的突破。
Int J Mol Sci. 2023 Feb 25;24(5):4544. doi: 10.3390/ijms24054544.
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The association between respiratory diseases and periodontitis: A systematic review and meta-analysis.呼吸道疾病与牙周炎的相关性：系统评价和荟萃分析。
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Systemic Antibiotics as an Adjunct to Subgingival Debridement: A Network Meta-Analysis.全身用抗生素作为龈下刮治的辅助治疗：一项网状荟萃分析。
Antibiotics (Basel). 2022 Nov 28;11(12):1716. doi: 10.3390/antibiotics11121716.
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