具有高热幅度的天然抗 - P1使ABO血型鉴定复杂化。

Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping.

作者信息

Ferdowsi Shirin, Mohammadi Saeed, Ahmadnezhad Moharram, Herfat Fahimeh, Rezvani Azita, Eshghi Peyman, Oodi Arezoo

机构信息

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Asian J Transfus Sci. 2024 Jan-Jun;18(1):135-137. doi: 10.4103/ajts.ajts_12_21. Epub 2022 May 26.

DOI:10.4103/ajts.ajts_12_21

PMID:39036675

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11259342/

Abstract

Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion. In the present study, we report three cases with ABO discrepancy due to anti-P1 that was identified as a cold-reacting antibody with high thermal amplitude.

摘要

抗 - P1 为免疫球蛋白 M 型，天然存在；它常被检测为一种弱反应性和冷反应性抗体。然而，在罕见情况下，它在 37°C 时有反应或表现出溶血性输血反应。抗 - P1 的高热幅度的存在不容忽视，输血时需要交叉配血相容的红细胞。在本研究中，我们报告了 3 例因抗 - P1 导致 ABO 血型不符的病例，该抗体被鉴定为具有高热幅度的冷反应性抗体。