Jang Siyeon, Lee Hyeonjin, Kim Hyeon Woo, Baek Minjae, Jung Sanghyun, Kim Sun Jung
Department of Life Science, Dongguk University-Seoul, Goyang, Republic of Korea.
J Ginseng Res. 2024 Jul;48(4):347-353. doi: 10.1016/j.jgr.2024.04.002. Epub 2024 Apr 14.
Ginsenosides in ginseng are known for their potential health benefits, including antioxidant properties and their potential to exhibit anticancer effects. Besides a various range of coding genes, ginsenosides impose their efficacy by targeting noncoding RNAs. Long noncoding RNA ( lncRNA) has gained significant attention from both basic and clinical oncology fields due to its involvement in various cancer cell activities such as proliferation, apoptosis, metastasis, and autophagy. These events can be achieved either by lncRNA alone or in association with microRNAs or proteins. This review aims to summarize the diverse activities of lncRNAs that are regulated by ginsenosides, focusing on their role in regulating target genes through signaling pathways in human diseases. We highlight the results of studies on the expression profiles of lncRNAs induced by ginsenosides in efforts to inhibit cancer cell proliferation. Finally, we discuss the potential and challenges of utilizing lncRNAs as diagnostic markers for disease treatment.
人参中的人参皂苷因其潜在的健康益处而闻名，包括抗氧化特性以及展现抗癌作用的潜力。除了一系列编码基因外，人参皂苷还通过靶向非编码RNA发挥其功效。长链非编码RNA（lncRNA）因其参与多种癌细胞活动，如增殖、凋亡、转移和自噬，而在基础肿瘤学和临床肿瘤学领域都受到了广泛关注。这些活动既可以由lncRNA单独实现，也可以与微小RNA或蛋白质共同作用实现。本综述旨在总结受人参皂苷调控的lncRNA的多样活动，重点关注它们在人类疾病中通过信号通路调控靶基因的作用。我们着重介绍了人参皂苷诱导lncRNA表达谱以抑制癌细胞增殖的研究结果。最后，我们讨论了将lncRNA用作疾病治疗诊断标志物的潜力和挑战。
