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韩国红参对运动性能和共济失调的影响。

Effect of Korean Red Ginseng on the motor performance and ataxia.

作者信息

Lee Seunghyun, Won Yeri, Kim Manho

机构信息

Medical School, Jeonbuk National University, Jeonju, Republic of Korea.

Biological Sciences Collegiate Division, The University of Chicago, Chicago, IL, USA.

出版信息

J Ginseng Res. 2024 Jul;48(4):425-427. doi: 10.1016/j.jgr.2024.03.008. Epub 2024 Mar 29.

DOI:10.1016/j.jgr.2024.03.008
PMID:39036735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11258376/
Abstract

This study presents a preliminary exploration into the effect of Korean Red Ginseng (KRG) on the cerebellum in individuals with cerebellar atrophy. Over a three month-long period, nine subjects received a 4.5g of KRG daily, with assessments including the ARS, ADAS-Cog, and FDG-PET/CT scans. Results revealed a notable improvement in ataxia and cognitive function without a significant correlation between them. PET/CT scans and SUVR analyses supported these findings, showing an increase in cerebellar glucose uptake after KRG intake. These outcomes suggest a potential pleiotropic effect of KRG on cerebellar function.

摘要

本研究初步探讨了高丽参(KRG)对小脑萎缩个体小脑的影响。在为期三个月的时间里,九名受试者每天服用4.5克高丽参,并进行包括ARS、ADAS-Cog和FDG-PET/CT扫描在内的评估。结果显示共济失调和认知功能有显著改善,但两者之间无显著相关性。PET/CT扫描和SUVR分析支持了这些发现,表明服用高丽参后小脑葡萄糖摄取增加。这些结果提示高丽参对小脑功能可能具有多效性作用。

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本文引用的文献

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Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.
2
The pons as reference region for intensity normalization in semi-quantitative analysis of brain FDG PET: application to metabolic changes related to ageing in conventional and digital control databases.脑 FDG PET 半定量分析中作为强度归一化参考区域的脑桥:在传统和数字对照数据库中与衰老相关的代谢变化的应用
EJNMMI Res. 2021 Mar 24;11(1):31. doi: 10.1186/s13550-021-00771-0.
3
Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study.
红参对人脑灰质体积和认知功能的影响:基于体素的形态测量学研究。
Hum Psychopharmacol. 2021 Mar;36(2):e2767. doi: 10.1002/hup.2767. Epub 2020 Nov 20.
4
Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer's disease.正常衰老和阿尔茨海默病的 FDG-PET 研究中最佳强度归一化区域的选择。
Sci Rep. 2020 Jun 9;10(1):9261. doi: 10.1038/s41598-020-65957-3.
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Brain Struct Funct. 2016 Sep;221(7):3503-19. doi: 10.1007/s00429-015-1116-6. Epub 2015 Sep 29.
6
Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial.韩国红参对认知和运动功能的影响:一项双盲、随机、安慰剂对照试验。
J Ginseng Res. 2012 Apr;36(2):190-7. doi: 10.5142/jgr.2012.36.2.190.
7
A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials.对人参在传统中医中的古代应用与现代药理实验及临床试验的比较。
Phytother Res. 2008 Jul;22(7):851-8. doi: 10.1002/ptr.2384.