Department of Surgical Oncology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Faculty of Life Sciences, BIOMED Research Institute, University Hasselt, Hasselt, Belgium.
Ann Surg Oncol. 2024 Oct;31(10):7090-7110. doi: 10.1245/s10434-024-15513-4. Epub 2024 Jul 22.
This manuscript reports the results of an international consensus on technologies of hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) performed with the following goals: To provide recommendations for the technological parameters to perform HIPEC. To identify the role of heat and its application forms in treating peritoneal metastases. To provide recommendations regarding the correct dosimetry of intraperitoneal chemotherapy drugs and their carrier solutions. To identify for each intraperitoneal chemotherapy regimen the best dosimetry and fractionation. To identify areas of future research pertaining to HIPEC technology and regimens. This consensus was performed by the Delphi technique and comprised two rounds of voting. In total, 96 of 102 eligible panelists replied to both Delphi rounds (94.1%) with a consensus of 39/51 questions on HIPEC technical aspects. Among the recommendations that met with the strongest consensus were those concerning the dose of HIPEC drug established in mg/m, a target temperature of at least 42°C, and the use of at least three temperature probes to pursue hyperthermia. Ninety minutes as the ideal HIPEC duration seemed to make consensus. These results should be considered when designing new clinical trials in patients with peritoneal surface malignancies.
这篇手稿报告了一项关于腹腔内热灌注化疗（HIPEC）技术的国际共识的结果，该共识的目的如下：提供关于 HIPEC 技术参数的建议。确定热及其应用形式在治疗腹膜转移中的作用。提供关于腹腔内化疗药物及其载体溶液正确剂量的建议。为每种腹腔内化疗方案确定最佳的剂量和分割。确定与 HIPEC 技术和方案相关的未来研究领域。这项共识是通过 Delphi 技术完成的，包括两轮投票。共有 102 名合格的小组成员中的 96 名回复了两轮 Delphi 投票（94.1%），对 51 个关于 HIPEC 技术方面的问题达成了共识。获得最强共识的建议包括：以 mg/m 为单位确定 HIPEC 药物的剂量、至少 42°C 的目标温度以及使用至少三个温度探头来进行高热治疗。90 分钟似乎是理想的 HIPEC 持续时间。在设计腹膜表面恶性肿瘤患者的新临床试验时，应考虑这些结果。
