School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu, 226019, P. R. China.
Chem Commun (Camb). 2024 Aug 9;60(65):8526-8536. doi: 10.1039/d4cc02596b.
As we all know, cancer is still a disease that we are struggling against. Although the traditional treatment options are still the mainstream in clinical practice, emerging phototheranostics technologies based on photoacoustic or fluorescence imaging-guided phototherapy also provide a new exploration direction for non-invasive, low-risk and highly efficient cancer treatment. Photosensitizers are the core materials to accomplish this mission. Recently, more attention has been paid to the emerging A-D-A fused-ring photosensitizers. A-D-A fused-ring photosensitizers display strong and wide absorption spectra, high photostability and easy molecular modification. Since this type of photosensitizer was first used for tumor therapy in 2019, its application boundaries are constantly expanding. Therefore, in this feature article, from the perspective of molecular design, we focused on the development of these molecules for application in phototheranostics over the past five years. The effects of tiny structural changes on their photophysical properties are discussed in detail, which provides a way for structural optimization of the subsequent A-D-A photosensitizers.
众所周知，癌症仍然是我们正在与之抗争的一种疾病。尽管传统的治疗选择仍然是临床实践中的主流，但基于光声或荧光成像引导光疗的新兴光热诊断治疗技术也为非侵入性、低风险和高效的癌症治疗提供了新的探索方向。光动力剂是完成这一任务的核心材料。最近，人们越来越关注新兴的 A-D-A 稠合环型光动力剂。A-D-A 稠合环型光动力剂具有较强和较宽的吸收光谱、高的光稳定性和易于分子修饰等特点。自 2019 年这种光动力剂首次用于肿瘤治疗以来，其应用范围不断扩大。因此，在这篇专题文章中，我们从分子设计的角度，重点介绍了过去五年中这些分子在光热诊断治疗中的应用发展。详细讨论了微小结构变化对其光物理性质的影响，为后续 A-D-A 光动力剂的结构优化提供了思路。
