一种用于高效缺氧肿瘤光热治疗的近红外二区发射型 I 型光敏剂。

An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics.

机构信息

State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.

School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, China.

出版信息

Chem Commun (Camb). 2024 May 14;60(40):5322-5325. doi: 10.1039/d4cc00431k.

DOI:10.1039/d4cc00431k

PMID:38666540

Abstract

A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push-pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS generation, showing encouraging therapeutic outcomes for hypoxic tumors.

摘要

合成了一种具有强推拉效应和良好平面π共轭结构的基于小分子的近红外二区 I 型光敏剂（IT-IC）。IT-IC NPs 表现出强的光吸收、出色的近红外二区荧光发射、优异的光热转换和高效的 I/II 型 ROS 生成，为缺氧肿瘤的治疗带来了可喜的结果。