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外泌体衍生的 microRNAs：白癜风中的新兴参与者。

Exosome-derived microRNAs: emerging players in vitiligo.

机构信息

School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Dermatological Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Immunol. 2024 Jul 8;15:1419660. doi: 10.3389/fimmu.2024.1419660. eCollection 2024.

DOI:10.3389/fimmu.2024.1419660
PMID:39040109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260631/
Abstract

Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale extracellular vesicles originating from intracellular compartments that are secreted by most cells into the extracellular space. This review examines the formation and function of exosomal miRNAs in biological information transfer, explores the pathogenesis of vitiligo, and highlights the relationship between exosomal miRNAs and vitiligo. The aim is to deepen the understanding of how exosomal miRNAs influence immune imbalance, oxidative stress damage, melanocyte-keratinocyte interactions, and melanogenesis disorders in the development of vitiligo. This enhanced understanding may contribute to the development of potential diagnostic and therapeutic options for vitiligo.

摘要

外泌体来源的 microRNAs（miRNAs）是生物大分子和纳米级细胞外囊泡，源自细胞内区室，由大多数细胞分泌到细胞外空间。本综述探讨了外泌体 miRNAs 在生物信息传递中的形成和功能，研究了白癜风的发病机制，并强调了外泌体 miRNAs 与白癜风之间的关系。目的是加深对外泌体 miRNAs 如何影响白癜风发病过程中的免疫失衡、氧化应激损伤、黑素细胞-角质形成细胞相互作用以及黑色素生成障碍的理解。这种深入的理解可能有助于开发白癜风潜在的诊断和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/fa26b964eded/fimmu-15-1419660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/aa86528f17b3/fimmu-15-1419660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/fa26b964eded/fimmu-15-1419660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/aa86528f17b3/fimmu-15-1419660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg

相似文献

[1]
Exosome-derived microRNAs: emerging players in vitiligo.

Front Immunol. 2024

[2]
Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.

J Cell Mol Med. 2020-10

[3]
Comprehensive Analysis of Exosomal MicroRNAs Derived from UVB-Irradiated Keratinocytes as Potential Melanogenesis Regulators.

Int J Mol Sci. 2024-3-7

[4]
New insight into the role of exosomes in vitiligo.

Autoimmun Rev. 2020-11

[5]
Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo.

J Invest Dermatol. 2022-12

[6]
MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes.

Acta Derm Venereol. 2016-8-23

[7]
Exosomal miRNA derived from keratinocytes regulates pigmentation in melanocytes.

J Dermatol Sci. 2019-3-12

[8]
Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo.

Cell Death Differ. 2016-3

[9]
Current insight into the roles of microRNA in vitiligo.

Mol Biol Rep. 2020-4

[10]
Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk.

Sci Rep. 2019-7-12

引用本文的文献

[1]
Topical Application of Bio-Pulsed Avian MSC-Derived Extracellular Vesicles Enhances Hair Regrowth and Skin Rejuvenation: Evidence from Clinical Evaluation and miRNA Profiling.

Curr Issues Mol Biol. 2025-7-11

[2]
Triple role of exosomes in lung transplantation.

Front Immunol. 2025-4-11

[3]
A comprehensive outline of the role of non-coding RNAs in vitiligo.

Biochem Biophys Rep. 2025-1-9

本文引用的文献

[1]
Innovative Diagnosis and Therapeutic Modalities: Engineered Exosomes in Autoimmune Disease.

Int J Nanomedicine. 2024

[2]
Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer.

Proc Natl Acad Sci U S A. 2024-4-16

[3]
Comprehensive Analysis of Exosomal MicroRNAs Derived from UVB-Irradiated Keratinocytes as Potential Melanogenesis Regulators.

Int J Mol Sci. 2024-3-7

[4]
Exosomes: The emerging mechanisms and potential clinical applications in dermatology.

Int J Biol Sci. 2024

[5]
Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies.

Cell Commun Signal. 2024-3-9

[6]
The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity.

Front Immunol. 2023

[7]
Exosomal miRNAs in autoimmune skin diseases.

Front Immunol. 2023

[8]
Oxidative Stress and Epigenetics: miRNA Involvement in Rare Autoimmune Diseases.

Antioxidants (Basel). 2023-3-25

[9]
Engineered exosomes from different sources for cancer-targeted therapy.

Signal Transduct Target Ther. 2023-3-15

[10]
Peripheral Blood of Vitiligo Patients-Derived Exosomal MiR-21-5p Inhibits Melanocytes Melanogenesis via Targeting SATB1.

Iran J Public Health. 2022-12

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