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外泌体衍生的 microRNAs：白癜风中的新兴参与者。

Exosome-derived microRNAs: emerging players in vitiligo.

机构信息

School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Dermatological Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Immunol. 2024 Jul 8;15:1419660. doi: 10.3389/fimmu.2024.1419660. eCollection 2024.

DOI:10.3389/fimmu.2024.1419660
PMID:39040109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260631/
Abstract

Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale extracellular vesicles originating from intracellular compartments that are secreted by most cells into the extracellular space. This review examines the formation and function of exosomal miRNAs in biological information transfer, explores the pathogenesis of vitiligo, and highlights the relationship between exosomal miRNAs and vitiligo. The aim is to deepen the understanding of how exosomal miRNAs influence immune imbalance, oxidative stress damage, melanocyte-keratinocyte interactions, and melanogenesis disorders in the development of vitiligo. This enhanced understanding may contribute to the development of potential diagnostic and therapeutic options for vitiligo.

摘要

外泌体来源的 microRNAs（miRNAs）是生物大分子和纳米级细胞外囊泡，源自细胞内区室，由大多数细胞分泌到细胞外空间。本综述探讨了外泌体 miRNAs 在生物信息传递中的形成和功能，研究了白癜风的发病机制，并强调了外泌体 miRNAs 与白癜风之间的关系。目的是加深对外泌体 miRNAs 如何影响白癜风发病过程中的免疫失衡、氧化应激损伤、黑素细胞-角质形成细胞相互作用以及黑色素生成障碍的理解。这种深入的理解可能有助于开发白癜风潜在的诊断和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/fa26b964eded/fimmu-15-1419660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/aa86528f17b3/fimmu-15-1419660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/fa26b964eded/fimmu-15-1419660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/aa86528f17b3/fimmu-15-1419660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/975e/11260631/9bb11d591250/fimmu-15-1419660-g003.jpg

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本文引用的文献

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Innovative Diagnosis and Therapeutic Modalities: Engineered Exosomes in Autoimmune Disease.创新诊断与治疗模式：工程化外泌体在自身免疫性疾病中的应用。
Int J Nanomedicine. 2024 May 1;19:3943-3956. doi: 10.2147/IJN.S452184. eCollection 2024.
2
Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer.角质细胞分泌的细胞外囊泡调节黑素体成熟、黑素细胞树突形态和色素转移。
Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2321323121. doi: 10.1073/pnas.2321323121. Epub 2024 Apr 12.
3
Comprehensive Analysis of Exosomal MicroRNAs Derived from UVB-Irradiated Keratinocytes as Potential Melanogenesis Regulators.
非编码RNA在白癜风中的作用综述
Biochem Biophys Rep. 2025 Jan 9;41:101916. doi: 10.1016/j.bbrep.2025.101916. eCollection 2025 Mar.
UVB 照射的角质细胞衍生的外泌体 microRNAs 的综合分析作为潜在的黑色素生成调控因子。
Int J Mol Sci. 2024 Mar 7;25(6):3095. doi: 10.3390/ijms25063095.
4
Exosomes: The emerging mechanisms and potential clinical applications in dermatology.外泌体：皮肤科新兴机制及潜在临床应用。
Int J Biol Sci. 2024 Feb 25;20(5):1778-1795. doi: 10.7150/ijbs.92897. eCollection 2024.
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Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies.外源性和内源性细胞外囊泡的标记策略及其在体外和体内功能研究中的应用。
Cell Commun Signal. 2024 Mar 9;22(1):171. doi: 10.1186/s12964-024-01548-3.
6
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