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本文引用的文献

1
Metformin as Host-Directed Therapy for TB Treatment: Scoping Review.二甲双胍作为结核病治疗的宿主导向疗法：范围综述
Front Microbiol. 2020 Apr 29;11:435. doi: 10.3389/fmicb.2020.00435. eCollection 2020.
2
Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review.二甲双胍对糖尿病患者结核病风险和治疗结局的影响：系统评价。
BMC Infect Dis. 2019 Oct 17;19(1):859. doi: 10.1186/s12879-019-4548-4.
3
The effects of diabetes on tuberculosis treatment outcomes: an updated systematic review and meta-analysis.糖尿病对结核病治疗结局的影响：一项更新的系统评价和荟萃分析。
Int J Tuberc Lung Dis. 2019 Jul 1;23(7):783-796. doi: 10.5588/ijtld.18.0433.
4
Metformin as a host-directed therapeutic in tuberculosis: Is there a promise?二甲双胍作为结核病的一种宿主导向治疗药物：是否有希望？
Tuberculosis (Edinb). 2019 Mar;115:76-80. doi: 10.1016/j.tube.2019.02.004. Epub 2019 Feb 13.
5
The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus.二甲双胍对糖尿病合并肺结核患者培养转化的影响。
Korean J Intern Med. 2018 Sep;33(5):933-940. doi: 10.3904/kjim.2017.249. Epub 2018 Mar 16.
6
The Risk of TB in Patients With Type 2 Diabetes Initiating Metformin vs Sulfonylurea Treatment.2 型糖尿病患者起始使用二甲双胍与磺酰脲类药物治疗的结核病风险。
Chest. 2018 Jun;153(6):1347-1357. doi: 10.1016/j.chest.2017.11.040. Epub 2017 Dec 16.
7
Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review.血糖控制及糖尿病治疗类型对结核合并糖尿病患者结核病治疗失败结局的影响：一项系统评价
PLoS One. 2017 Oct 23;12(10):e0186697. doi: 10.1371/journal.pone.0186697. eCollection 2017.
8
[Metformin - mechanisms of action and use for the treatment of type 2 diabetes mellitus].[二甲双胍——作用机制及用于治疗2型糖尿病]
Postepy Hig Med Dosw (Online). 2011 May 6;65:277-85. doi: 10.5604/17322693.941655.
9
Clinical characteristics of patients with type 2 diabetes mellitus at the time of insulin initiation: INSTIGATE observational study in Spain.初诊 2 型糖尿病患者的临床特征：西班牙 INSTIGATE 观察性研究。
Acta Diabetol. 2010 Dec;47 Suppl 1(Suppl 1):169-75. doi: 10.1007/s00592-009-0158-8. Epub 2009 Oct 24.

二甲双胍可降低利福平耐药结核病合并2型糖尿病患者治疗效果不佳的风险。

Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus.

作者信息

Salindri Argita D, Gujabidze Mariam, Kipiani Maia, Lomtadze Nino, Tukvadze Nestani, Avaliani Zaza, Blumberg Henry M, Kornfeld Hardy, Kempker Russell R, Magee Matthew J

机构信息

Department of Population Health Sciences, Georgia State University School of Public Health, Atlanta, GA, USA.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, USA.

出版信息

medRxiv. 2024 Jul 14:2024.07.12.24310348. doi: 10.1101/2024.07.12.24310348.

DOI:10.1101/2024.07.12.24310348
PMID:39040177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261920/
Abstract

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.06 - 0.95) compared to those without.

摘要

我们对耐利福平结核病合并糖尿病患者进行了一项回顾性队列研究，以确定使用二甲双胍与结核病治疗结局之间的关联。我们发现，与未使用二甲双胍的患者相比，使用二甲双胍的患者出现不良结核病治疗结局的风险显著更低（校正风险比=0.25，95%置信区间0.06 - 0.95）。