Honda Pazili Takahiro
Regenerative Medicine Department of Cell Therapy Japan Tokyo Stem Cell Transplant Research Institute Ginza Clinic, Ginza 4-3-9, Chuo-ku, Tokyo 104-0067, Japan.
Case Rep Neurol Med. 2024 Jul 15;2024:8353492. doi: 10.1155/2024/8353492. eCollection 2024.
Alzheimer's disease (AD) is a progressive neurological disorder and is the most common form of dementia. The terminal stage of AD is characterized by severe cognitive and substantial functional decline, requiring extensive assistance with daily activities. As effective therapies at this stage are not fully available, development of therapeutics that can recover any symptoms would be important to improve the quality of life. Recently, stem cell therapy has gathered a lot of attention in several neurological diseases, including AD. Here, we report an AD patient at the terminal stage whose symptoms were improved by the intravenous administration of -expanded bone marrow-derived mesenchymal stem cells (MSC). The case is a 61-year-old woman with severe Alzheimer's disease who had been admitted to the special nursing home. She could neither walk nor sit up independently. She also did neither smile nor gaze properly when talked to. Rigidity including neck motion was observed. She was on dysphagia diets. We cultured her bone-marrow-derived MSCs and intravenously administered 1,5 × 10 cells. After the treatment, smile loss, eye movement dysfunction, and neck immobility were improved. This is the first case report that showed the therapeutic effects of MSCs on terminal symptoms of AD.
阿尔茨海默病（AD）是一种进行性神经疾病，也是最常见的痴呆形式。AD的终末期以严重的认知和显著的功能衰退为特征，需要在日常活动中得到广泛帮助。由于现阶段尚无有效的治疗方法，开发能够缓解任何症状的疗法对于提高生活质量至关重要。最近，干细胞疗法在包括AD在内的几种神经疾病中受到了广泛关注。在此，我们报告了一名AD终末期患者，其症状通过静脉注射扩增的骨髓间充质干细胞（MSC）得到改善。该病例为一名61岁患有重度阿尔茨海默病的女性，她已入住特殊护理院。她既无法独立行走，也无法坐起。与人交谈时，她既不微笑，目光也不正常。观察到包括颈部活动在内的僵硬情况。她采用吞咽困难饮食。我们培养了她的骨髓间充质干细胞，并静脉注射了1.5×10个细胞。治疗后，笑容丧失、眼球运动功能障碍和颈部活动受限均有所改善。这是首例显示间充质干细胞对AD终末期症状具有治疗效果的病例报告。
