[骨髓细胞在致死性照射动物中恢复血小板生成的能力]
[Capacity of bone marrow cells to restore thrombocytopoiesis in lethally irradiated animals].
作者信息
Selivanov V A, Akhmadieva A Kh
出版信息
Tsitologiia. 1985 Aug;27(8):928-32.
PMID:3904098
Abstract
A study was made of the kinetics of thrombocytopoiesis restoration in lethally irradiated mice after transplantation to them of the donor marrow cells. In the initial period, the thrombocytopoiesis restoration is provided by transite cells-precursors of megakaryocytes present in the transplanted bone marrow; the subsequent restoration is due to cells of the self-maintaining population. The level of restoration does not correlate with the number of polypotent cells that form macrocolonies in the spleen of irradiated recipients.
摘要
对接受供体骨髓细胞移植的致死性照射小鼠血小板生成恢复的动力学进行了研究。在初始阶段，血小板生成的恢复是由移植骨髓中存在的过渡细胞——巨核细胞前体提供的；随后的恢复是由于自我维持群体的细胞。恢复水平与在受照射受体脾脏中形成大集落的多能细胞数量无关。
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