2017-2019 年加拿大城市男同性恋、双性恋和其他男男性行为者中口腔人乳头瘤病毒感染的流行率。
Prevalence of Oral Human Papillomavirus Infection Among Urban Gay, Bisexual, and Other Men Who Have Sex With Men in Canada, 2017-2019.
机构信息
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Quebec, Canada.
出版信息
J Infect Dis. 2024 Nov 15;230(5):e1039-e1048. doi: 10.1093/infdis/jiae345.
BACKGROUND
Oral human papillomavirus (HPV) infections are a leading cause of oropharyngeal cancers. In 2015 and 2016, HPV vaccines became publicly funded for gay, bisexual, and other men who have sex with men (GBM) under 27 years of age in most Canadian provinces.
METHODS
Between 2017 and 2019, sexually active GBM in Montreal, Toronto, and Vancouver were recruited through respondent-driven sampling. Participants aged 16-30 years were invited to self-collect oral rinse specimens for HPV testing. We estimated HPV prevalence in the oral tract overall and compared these by vaccination status.
RESULTS
Among the 838 GBM with a valid oral specimen, 36.9% reported receiving ≥1 dose of HPV vaccine. Overall, oral HPV prevalence was 2.6% (95% confidence interval [CI], 1.5%-3.7%) for at least 1 HPV type and 1.2% (95% CI, .5%-1.9%) for any high-risk type. We detected quadrivalent (HPV 6/11/16/18) vaccine-preventable types in 0.3% (95% CI, .0%-1.0%) of vaccinated individuals and 1.1% (95% CI, .1%-2.0%) of unvaccinated individuals.
CONCLUSIONS
Oral HPV prevalence was low in a population of young urban GBM in Canada, of whom 37% were vaccinated. Findings serve as a benchmark for monitoring of vaccination impacts on oral HPV infection within this priority population.
背景
口腔人乳头瘤病毒（HPV）感染是口咽癌的主要病因。2015 年和 2016 年，在加拿大大多数省份，27 岁以下的男同性恋者、双性恋者和其他与男性发生性关系者（GBM）可获得 HPV 疫苗的公共资助。
方法
在 2017 年至 2019 年间，通过应答者驱动抽样法在蒙特利尔、多伦多和温哥华招募活跃的 GBM 参与者。邀请年龄在 16-30 岁之间的参与者自行采集口腔冲洗样本进行 HPV 检测。我们估计了整个口腔的 HPV 流行率，并按疫苗接种状况进行了比较。
结果
在 838 名具有有效口腔标本的 GBM 中，36.9%报告至少接种了 1 剂 HPV 疫苗。总体而言，至少 1 种 HPV 型别的口腔 HPV 流行率为 2.6%（95%置信区间[CI]，1.5%-3.7%），任何高危型别的流行率为 1.2%（95% CI，.5%-1.9%）。我们在接种疫苗的个体中检测到四价疫苗（HPV 6/11/16/18）可预防的类型占 0.3%（95% CI，.0%-1.0%），在未接种疫苗的个体中占 1.1%（95% CI，.1%-2.0%）。
结论
在加拿大年轻的城市 GBM 人群中，口腔 HPV 流行率较低，其中 37%的人接种了疫苗。这些发现为监测该重点人群中疫苗接种对口咽 HPV 感染的影响提供了基准。
Zotero 插件