Department of Rheumatology and Immunology, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou City, Zhejiang Province, China.
PLoS One. 2024 Jul 23;19(7):e0307599. doi: 10.1371/journal.pone.0307599. eCollection 2024.
Statins have anti-inflammatory and immune-modulatory effects which could alter the risk of rheumatoid arthritis (RA). We reviewed published literature and conducted a meta-analysis to examine if statins have an impact on the risk of RA.
Case-control studies, cohort studies, or randomized controlled trials (RCT) published on the PubMed, Scopus, and EMBASE databases up to 30th October 2023 were searched. The association between statin use and risk of RA was pooled in a random-effects meta-analysis.
Nine studies (four cohort, four case-control, and one RCT) were included. Overall, the analysis failed to note an association between the use of statins and the risk of RA with the pooled OR being 0.93 (95% CI 0.82, 1.06). High heterogeneity was noted with I2 = 75%. Results were consistent across study types with no association noted between prior statin use and risk of RA in case-control studies (OR: 0.88 95% CI: 0.69, 1.13), cohort studies (OR: 1.01 95% CI: 0.92, 1.10), and the lone RCT (OR: 1.40 95% CI: 0.50, 3.92).
Current literature shows that there is no association between the use of statins and the risk of RA. Further rigorous studies taking into account patient factors, duration of statin exposure, and other confounders are needed to generate better evidence.
他汀类药物具有抗炎和免疫调节作用，可能改变类风湿关节炎（RA）的风险。我们回顾了已发表的文献，并进行了荟萃分析，以检查他汀类药物是否会影响 RA 的风险。
检索了截至 2023 年 10 月 30 日在 PubMed、Scopus 和 EMBASE 数据库中发表的病例对照研究、队列研究或随机对照试验（RCT）。使用随机效应荟萃分析汇总了他汀类药物使用与 RA 风险之间的关联。
共纳入了 9 项研究（4 项队列研究、4 项病例对照研究和 1 项 RCT）。总体而言，分析未能表明他汀类药物的使用与 RA 风险之间存在关联，合并的 OR 为 0.93（95%CI 0.82,1.06）。存在高度异质性，I2=75%。研究类型之间的结果一致，在病例对照研究中，他汀类药物的使用与 RA 风险之间没有关联（OR：0.88 95%CI：0.69,1.13），在队列研究中（OR：1.01 95%CI：0.92,1.10），以及唯一的 RCT 中（OR：1.40 95%CI：0.50,3.92）。
目前的文献表明，他汀类药物的使用与 RA 的风险之间没有关联。需要进一步进行严格的研究，考虑患者因素、他汀类药物暴露时间和其他混杂因素，以产生更好的证据。
