Associate Professor, Department of General Surgery (Endocrine Surgery), All India Institute of Medical Sciences, Patna, India.
Additional Professor, Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, India.
Trop Doct. 2024 Oct;54(4):340-345. doi: 10.1177/00494755241264043. Epub 2024 Jul 23.
The availability of radioisotopes for sentinel lymph node biopsy (SLNB) in breast carcinoma is limited in low- and middle-income countries and thus the need for other reliable tracers exists. We aimed to validate the effectiveness of fluorescein sodium (FS) together with methylene blue dye (MBD) for patients with node-negative early breast carcinoma in a prospective cross-sectional study. Patients underwent SLNB using FS and MBD followed by axillary dissection to validate results. Sentinel lymph node (SLN) identification rate and false negative rate were assessed for all three tracers/combinations (MBD, FS, and MBD + FS). We concluded that SLNB using a combination of FS and MBD has an acceptable rate of SLN identification but the addition of FS provided no additional benefit.
在乳腺癌的前哨淋巴结活检 (SLNB) 中，放射性同位素的可用性在低收入和中等收入国家受到限制，因此需要其他可靠的示踪剂。我们旨在通过前瞻性横断面研究验证荧光素钠 (FS) 联合亚甲蓝染料 (MBD) 在淋巴结阴性早期乳腺癌患者中的有效性。患者接受 FS 和 MBD 进行 SLNB 后进行腋窝清扫以验证结果。评估了所有三种示踪剂/组合（MBD、FS 和 MBD+FS）的前哨淋巴结 (SLN) 识别率和假阴性率。我们得出结论，FS 和 MBD 联合使用的 SLNB 具有可接受的 SLN 识别率，但添加 FS 没有提供额外的益处。
