From physical to digital: A theoretical-methodological primer on designing hyperscanning investigations to explore remote exchanges.

As individuals increasingly engage in social interactions through digital mediums, understanding the neuroscientific underpinnings of such exchanges becomes a critical challenge and a valuable opportunity. In line with a second-person neuroscience approach, understanding the forms of interpersonal syntonisation that occur during digital interactions is pivotal for grasping the mechanisms underlying successful collaboration in virtual spaces. The hyperscanning paradigm, involving the simultaneous monitoring of the brains and bodies of multiple interacting individuals, seems to be a powerful tool for unravelling the neural correlates of interpersonal syntonisation in social exchanges. We posit that such approach can now open new windows on interacting brains' responses even to digitally-conveyed social cues, offering insights into how social information is processed in the absence of traditional face-to-face settings. Yet, such paradigm shift raises challenging methodological questions, which should be answered properly to conduct significant and informative hyperscanning investigations. Here, we provide an introduction to core methodological issues dedicated to novices approaching the design of hyperscanning investigations of remote exchanges in natural settings, focusing on the selection of neuroscientific devices, synchronization of data streams, and data analysis approaches. Finally, a methodological checklist for devising robust hyperscanning studies on digital interactions is presented.