在法国东北部白纹伊蚊传播日益增多的地区，返回旅行者中虫媒病毒感染的漏诊情况。
Underdiagnosis of arbovirus infections in returned travelers in an area with growing circulation of Aedes albopictus in North-Eastern France.
机构信息
Virology Laboratory, Strasbourg University Hospital, Strasbourg, France.
Virology Laboratory, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, Strasbourg University, Strasbourg France.
出版信息
Infect Dis Now. 2024 Oct;54(7):104956. doi: 10.1016/j.idnow.2024.104956. Epub 2024 Jul 21.
BACKGROUND
Vector-borne diseases such as malaria and arboviruses are common etiologies of post-travel fever.
METHODS
After excluding malaria, we retrospectively analyzed the diagnosis of dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) infections following recent travel by patients treated at the Strasbourg University Hospital between 2014 and 2023. Available serums (n = 35) sampled in 2023 were retrospectively tested for DENV, CHIKV, and ZIKV infections.
RESULTS
Our results showed that 78% of the 915 malaria-negative patients without changes over the course of ten years had not undergone arbovirus infection testing. Retrospective testing revealed missing arbovirus infections: two DENV infections and one CHIKV infection, representing 8.6% (3/35) of patients for whom no mandatory declaration or vector control could be undertaken.
CONCLUSION
Our results highlight the need for early case detection, particularly in the context of the upcoming 2024 Olympic Games.
背景
疟疾和虫媒病毒等虫媒病是旅行后发热的常见病因。
方法
排除疟疾后，我们回顾性分析了 2014 年至 2023 年期间斯特拉斯堡大学医院治疗的近期旅行后患者的登革热病毒（DENV）、基孔肯雅热病毒（CHIKV）和寨卡病毒（ZIKV）感染的诊断。对 2023 年采集的 35 份可用血清进行了回顾性检测，以检测 DENV、CHIKV 和 ZIKV 感染情况。
结果
我们的结果表明，10 年来，915 例疟疾阴性且病情无变化的患者中，有 78%未进行虫媒病毒感染检测。回顾性检测发现了缺失的虫媒病毒感染：两例 DENV 感染和一例 CHIKV 感染，占未进行强制性申报或病媒控制的 35 例患者中的 8.6%（3/35）。
结论
我们的结果强调了早期病例检测的必要性，特别是在即将到来的 2024 年奥运会背景下。
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