KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven 3000, Belgium.
Xiangya School of Public Health, Central South University, Changsha 410078, China.
Biochem Pharmacol. 2024 Oct;228:116448. doi: 10.1016/j.bcp.2024.116448. Epub 2024 Jul 21.
Many acyclic nucleoside phosphonates such as cidofovir, adefovir dipivoxil, tenofovir disoproxil fumarate, and tenofovir alafenamide have been marketed for the treatment or prophylaxis of infectious diseases. Here, this review highlights potent acyclic nucleoside phosphonates for their potential in the treatment of retrovirus (e.g., human immunodeficiency virus) and DNA virus (e.g., adeno-, papilloma-, herpes- and poxvirus) infections. If properly assessed and/or optimized, some potent acyclic nucleoside phosphonates can be possibly applied in the control of current and emerging infectious diseases.
许多无环核苷膦酸酯类化合物，如西多福韦、阿德福韦酯、富马酸替诺福韦二吡呋酯和替诺福韦艾拉酚胺，已被用于治疗或预防传染病。在这里，本综述重点介绍了具有潜力的无环核苷膦酸酯类化合物，因为它们有可能用于治疗逆转录病毒（例如，人类免疫缺陷病毒）和 DNA 病毒（例如，腺病毒、乳头瘤病毒、疱疹病毒和痘病毒）感染。如果经过适当评估和/或优化，一些有效的无环核苷膦酸酯类化合物有可能用于控制当前和新出现的传染病。
