Emerg Infect Dis. 2024 Aug;30(8):1545-1554. doi: 10.3201/eid3008.231671.
Human infections with Corynebacterium diphtheriae species complex (CdSC) bacteria were rare in French Guiana until 2016, when the number of cases diagnosed increased. We conducted an epidemiologic, multicenter, retrospective study of all human CdSC infections diagnosed in French Guiana during January 1, 2016-December 31, 2021. A total of 64 infectious episodes were observed in 60 patients; 61 infections were caused by C. diphtheriae and 3 by C. ulcerans. Estimated incidence increased from 0.7 cases/100,000 population in 2016 to 7.7 cases/100,000 population in 2021. The mean patient age was 30.4 (+23.7) years, and male-to-female ratio was 1.7:1 (38/22). Of the 61 C. diphtheriae isolates, 5 tested positive for the diphtheria toxin gene, and all results were negative by Elek test; 95% (61/64) of cases were cutaneous, including the C. ulcerans cases. The increase in reported human infections underscores the need to raise awareness among frontline healthcare practitioners to improve prevention.
法属圭亚那直到 2016 年之前，人类感染白喉棒状杆菌复合群（CdSC）细菌的情况较为罕见，但此后确诊病例数量开始增加。我们开展了一项针对 2016 年 1 月 1 日至 2021 年 12 月 31 日期间法属圭亚那所有 CdSC 感染病例的流行病学、多中心、回顾性研究。共观察到 60 例患者中的 64 个感染期；61 例感染由白喉棒状杆菌引起，3 例由溃疡棒状杆菌引起。估计发病率从 2016 年的每 10 万人 0.7 例上升至 2021 年的每 10 万人 7.7 例。患者平均年龄为 30.4（+23.7）岁，男女比例为 1.7:1（38/22）。61 株白喉棒状杆菌分离株中，5 株检测到白喉毒素基因阳性，Elek 试验全部结果均为阴性；95%（61/64）的病例为皮肤感染，包括溃疡棒状杆菌感染病例。报告的人类感染病例增加，突显了提高一线医护人员防范意识的必要性，以改善预防措施。
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