Emerg Infect Dis. 2024 Aug;30(8):1631-1641. doi: 10.3201/eid3008.240209.
A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV classification on the basis of the challenges and limitations of our previous proposals and the future of genomic surveillance. From a high-quality curated dataset of 1,480 HRSV-A and 1,385 HRSV-B genomes submitted to GenBank and GISAID (https://www.gisaid.org) public sequence databases through March 2023, we categorized HRSV-A/B sequences into lineages based on phylogenetic clades and amino acid markers. We defined 24 lineages within HRSV-A and 16 within HRSV-B and provided guidelines for defining prospective lineages. Our classification demonstrated robustness in its applicability to both complete and partial genomes. We envision that this unified HRSV classification proposal will strengthen HRSV molecular epidemiology on a global scale.
目前仍难以在亚群以下的水平对全球通用的人类呼吸道合胞病毒（HRSV）进行统一的系统发育分类。我们根据之前提案的挑战和局限性以及基因组监测的未来，制定了 HRSV 分类的全球共识。从 2023 年 3 月之前提交到 GenBank 和 GISAID（https://www.gisaid.org）公共序列数据库的高质量经过精心整理的 1480 个 HRSV-A 和 1385 个 HRSV-B 基因组的数据集，我们根据系统发育枝和氨基酸标记将 HRSV-A/B 序列分为谱系。我们在 HRSV-A 中定义了 24 个谱系，在 HRSV-B 中定义了 16 个谱系，并提供了定义潜在谱系的指南。我们的分类在适用于完整和部分基因组方面表现出稳健性。我们设想，这个统一的 HRSV 分类提案将加强全球范围内的 HRSV 分子流行病学。
