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一个 sbiT-sbiRS-gloIo 调控回路参与嗜麦芽寡养单胞菌的氧化应激耐受。

A sbiT-sbiRS-gloIo regulatory circuit is involved in oxidative stress tolerance of Stenotrophomonas maltophilia.

机构信息

Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

出版信息

J Microbiol Immunol Infect. 2024 Oct;57(5):827-831. doi: 10.1016/j.jmii.2024.07.005. Epub 2024 Jul 14.

DOI:10.1016/j.jmii.2024.07.005
PMID:39043487
Abstract

The sbiT-sbiR-sbiS operon of Stenotrophomonas maltophilia encodes an inner-membrane protein SbiT and a SbiS-SbiR two-component regulatory system. A sbiT mutant displayed a growth defect in LB agar. Mechanism studies revealed that sbiT deletion resulted in SbiSR activation and gloIo upregulation, which increased intracellular ROS level and caused growth defect.

摘要

嗜麦芽寡养单胞菌的 sbiT-sbiR-sbiS 操纵子编码一个内膜蛋白 SbiT 和一个 SbiS-SbiR 双组分调控系统。sbiT 突变体在 LB 琼脂上表现出生长缺陷。机制研究表明，sbiT 缺失导致 SbiSR 激活和 gloIo 上调，增加了细胞内 ROS 水平并导致生长缺陷。

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