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慢性胰腺炎患者的全胰头部切除术-一种新手术技术的结果。

Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique.

机构信息

Dept. of Surgical Gastroenterology, JIPMER, Puducherry, India.

Dept. of Surgical Gastroenterology, JIPMER, Puducherry, India.

出版信息

Pancreatology. 2024 Sep;24(6):954-959. doi: 10.1016/j.pan.2024.07.003. Epub 2024 Jul 18.

DOI:10.1016/j.pan.2024.07.003
PMID:39043488
Abstract

BACKGROUND

Chronic pancreatitis (CP) is characterized by debilitating pain which affects patients' quality of life. Early surgical intervention has been shown to mitigate pain and prevent a decline in quality of life. The present study evaluated the impact of bile duct and duodenum preserving pancreatic head resection (BDPPHR), an innovative technique, on pain relief, functional outcomes, postoperative morbidity, and mortality in patients with CP.

METHODS

Between March 2019 and July 2022, a total of 37 patients underwent bile duct and duodenum preserving pancreatic head resection (BDPPHR) for pain relief in patients with CP. Post-operative outcomes were assessed by Izbicki pain score, exocrine insufficiency, endocrine insufficiency, and return to work. The safety of the surgical procedure was determined by evaluation of postoperative morbidity and mortality as per Clavien-Dindo scores.

RESULTS

BDPPHR showed a significant reduction in Izbicki pain scores with 30 (81 %) patients experiencing complete or partial pain relief up to 18 months of follow up. 32(86 %) patients ceased narcotic use by the end of the 18-month follow-up period. 33 (89 %) patients were able to resume regular work at the end of 18 months. There were no significant alterations in both exocrine and endocrine statuses post-surgery. The median duration of hospital stay was 4.5 days (3-11). Major complications occurred in 2 (5 %) patients. There was no post-operative mortality.

CONCLUSION

BDPPHR is a novel and safe technique of near total head resection which results in very good pain relief in 81 % of patients.

摘要

背景

慢性胰腺炎(CP)的特征是疼痛,这会影响患者的生活质量。早期手术干预已被证明可以减轻疼痛并防止生活质量下降。本研究评估了保留胆管和十二指肠的胰头切除术(BDPPHR)对 CP 患者的疼痛缓解、功能结局、术后发病率和死亡率的影响。

方法

2019 年 3 月至 2022 年 7 月,共有 37 例患者因 CP 疼痛而行保留胆管和十二指肠的胰头切除术(BDPPHR)。通过 Izbicki 疼痛评分、外分泌不足、内分泌不足和重返工作岗位来评估术后结局。通过 Clavien-Dindo 评分评估术后发病率和死亡率来确定手术的安全性。

结果

BDPPHR 显示 Izbicki 疼痛评分显著降低,30 例(81%)患者在 18 个月的随访中经历完全或部分疼痛缓解。32 例(86%)患者在 18 个月的随访结束时停止使用麻醉药物。33 例(89%)患者在 18 个月结束时能够恢复正常工作。术后外分泌和内分泌状态均无明显改变。中位住院时间为 4.5 天(3-11 天)。2 例(5%)患者发生重大并发症。无术后死亡。

结论

BDPPHR 是一种全新的、安全的近全胰头切除术技术,81%的患者疼痛缓解效果非常好。

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