Qian Huiqin, Li Yanling
College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang, China.
Front Pharmacol. 2024 Jul 9;15:1407140. doi: 10.3389/fphar.2024.1407140. eCollection 2024.
Nandina domestica: Thunb. is a traditional Chinese herbal drug that has long been used in China and Japan for the treatment of colds, fevers, asthma, chronic bronchitis, conjunctivitis, whooping cough, pharyngeal tumors, etc. Published data have reported at least 366 constituents from , including alkaloids, flavonoids, lignans, terpenoids, phenolic acids and their derivatives, fatty acids, and others. Of these, the isoquinoline alkaloids are considered characteristic markers for . These alkaloids also showed the most promising bioactivities. The crude extracts or semi-purified constituents of exhibit a variety of activities, including antitumor, dermatological, anti-inflammatory, antioxidant, antimicrobial, and detoxification activities, as well as effects on respiratory system, etc. The fruit is considered poisonous when eaten raw, with nausea, vomiting, diarrhea, and abdominal pain as side effects after ingestion. Most traditional uses are supported by biological activities demonstrated in modern experimental studies, suggesting a potential medicinal value of . However, more information is needed on its mechanisms of activity, pharmacokinetic profile of the constituents, and its safety and efficacy profile in humans.
Thunb. 是一种传统的中草药，在中国和日本长期用于治疗感冒、发烧、哮喘、慢性支气管炎、结膜炎、百日咳、咽部肿瘤等。已发表的数据报道了南天竹中至少366种成分，包括生物碱、黄酮类化合物、木脂素、萜类化合物、酚酸及其衍生物、脂肪酸等。其中，异喹啉生物碱被认为是南天竹的特征性标志物。这些生物碱也表现出最有前景的生物活性。南天竹的粗提取物或半纯化成分具有多种活性，包括抗肿瘤、皮肤病学、抗炎、抗氧化、抗菌和解毒活性，以及对呼吸系统等的影响。南天竹的果实生食时被认为有毒，摄入后会出现恶心、呕吐、腹泻和腹痛等副作用。大多数传统用途都得到了现代实验研究中所证明的生物活性的支持，这表明南天竹具有潜在的药用价值。然而，关于其活性机制、成分的药代动力学特征以及其在人体中的安全性和有效性特征，还需要更多信息。
