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Confirmation of large BRCA2 reversion deletions leading to reconstituted in-frame transcripts detected via circulating tumor DNA.

作者信息

Collier K A, Stover D G

机构信息

Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus; Pelotonia Institute for Immuno-Oncology, Ohio State University Comprehensive Cancer, Columbus.

Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus; Pelotonia Institute for Immuno-Oncology, Ohio State University Comprehensive Cancer, Columbus; Department of Biomedical Informatics, Ohio State University, Columbus, USA.

出版信息

Ann Oncol. 2024 Oct;35(10):917-919. doi: 10.1016/j.annonc.2024.07.720. Epub 2024 Jul 22.

DOI:10.1016/j.annonc.2024.07.720
PMID:39048081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998630/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfb/11998630/f31a61d33c67/nihms-2072417-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfb/11998630/f31a61d33c67/nihms-2072417-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfb/11998630/f31a61d33c67/nihms-2072417-f0001.jpg

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本文引用的文献

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Ann Oncol. 2024 Apr;35(4):364-380. doi: 10.1016/j.annonc.2024.01.003. Epub 2024 Jan 19.
2
Association of 17q22 Amplicon Via Cell-Free DNA With Platinum Chemotherapy Response in Metastatic Triple-Negative Breast Cancer.游离 DNA 中 17q22 扩增与转移性三阴性乳腺癌铂类化疗反应的关联。
JCO Precis Oncol. 2021 Nov 24;5. doi: 10.1200/PO.21.00104. eCollection 2021.
3
Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.
通过转移性乳腺癌的循环肿瘤 DNA 对狭窄时间范围内的克隆结构进行建模。
Genome Med. 2021 May 20;13(1):89. doi: 10.1186/s13073-021-00895-x.
4
PARP inhibitors: Synthetic lethality in the clinic.聚（ADP-核糖）聚合酶抑制剂：临床中的合成致死性
Science. 2017 Mar 17;355(6330):1152-1158. doi: 10.1126/science.aam7344. Epub 2017 Mar 16.
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Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?分子通路：BRCA 突变型肿瘤如何对 PARP 抑制剂产生耐药性？
Clin Cancer Res. 2014 Feb 1;20(3):540-7. doi: 10.1158/1078-0432.CCR-13-0225. Epub 2013 Nov 22.