Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
BMC Cancer. 2024 Jul 25;24(1):894. doi: 10.1186/s12885-024-12614-x.
Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers and 11th in cancer-related deaths globally, with 474,519 new cases and 311,594 deaths (GLOBOCAN2020). Research into leukemia's development mechanisms may lead to new treatments. Ubiquitin-specific proteases (USPs), a family of deubiquitinating enzymes, play critical roles in various biological processes, with both tumor-suppressive and oncogenic functions, though a comprehensive understanding is still needed.
This systematic review aimed to provide a comprehensive review of how Ubiquitin-specific proteases are involved in pathogenesis of different types of leukemia.
We systematically searched the MEDLINE (via PubMed), Scopus, and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) to identify relevant studies focusing on the role of USPs in leukemia. Data from selected articles were extracted, synthesized, and organized to present a coherent overview of the subject matter.
The review highlights the crucial roles of USPs in chromosomal aberrations, cell proliferation, differentiation, apoptosis, cell cycle regulation, DNA repair, and drug resistance. USP activity significantly impacts leukemia progression, inhibition, and chemotherapy sensitivity, suggesting personalized diagnostic and therapeutic approaches. Ubiquitin-specific proteases also regulate gene expression, protein stability, complex formation, histone deubiquitination, and protein repositioning in specific leukemia cell types.
The diagnostic, prognostic, and therapeutic implications associated with ubiquitin-specific proteases (USPs) hold significant promise and the potential to transform leukemia management, ultimately improving patient outcomes.
白血病是一种血癌，根据受影响的白细胞类型（淋巴细胞或髓样细胞）和疾病进展情况（急性或慢性）进行分类。2020 年，它在全球最常见的癌症中排名第 15 位，癌症相关死亡中排名第 11 位，新发病例为 474519 例，死亡病例为 311594 例（GLOBOCAN2020）。对白血病发病机制的研究可能会带来新的治疗方法。泛素特异性蛋白酶（USPs）是去泛素化酶家族，在各种生物过程中发挥着关键作用，具有抑癌和致癌功能，但仍需要全面了解。
本系统综述旨在全面综述泛素特异性蛋白酶如何参与不同类型白血病的发病机制。
我们根据系统评价和荟萃分析的首选报告项目（PRISMA），系统地检索了 MEDLINE（通过 PubMed）、Scopus 和 Web of Science 数据库，以确定专注于 USPs 在白血病中作用的相关研究。从选定的文章中提取、综合和组织数据，以呈现主题的连贯概述。
综述强调了 USPs 在染色体异常、细胞增殖、分化、凋亡、细胞周期调控、DNA 修复和耐药性方面的关键作用。USP 活性显著影响白血病的进展、抑制和化疗敏感性，提示采用个性化的诊断和治疗方法。泛素特异性蛋白酶还调节特定白血病细胞类型中的基因表达、蛋白质稳定性、复合物形成、组蛋白去泛素化和蛋白质重定位。
与泛素特异性蛋白酶（USPs）相关的诊断、预后和治疗意义具有重要意义，有潜力改变白血病的管理，最终改善患者的预后。
