基于土耳其数据库的研究：乳糜泻对贝赫切特综合征患者的影响
Impact of celiac disease in Behçet's syndrome patients: a study based on the database of Türkiye.
机构信息
Department of Internal Medicine Sciences, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkiye.
Department of Strategy Development, Republic of Türkiye Ministry of Health, Ankara, Turkiye.
出版信息
Turk J Med Sci. 2024 May 7;54(3):493-501. doi: 10.55730/1300-0144.5815. eCollection 2024.
BACKGROUND/AIM: Our primary aim was to investigate the effects of concomitant celiac disease (CD) on the clinical characteristics of Behçet's syndrome (BS) patients.
MATERIALS AND METHOD
The study was a retrospective, nationwide, multicenter study. Turkish Ministry of Health National Electronic Database (e-Nabız) is used under Health Ministry's supervision to extract the subject's data.
STATISTICAL ANALYSIS
Statistical analyses were made by the Statistical Package for Social Sciences (SPSS) software version 20 (IBM Corp., Armonk, New York). Continuous variables were presented by mean ± standard derivation (SD) or median (min-max) according to normality and compared by student-t test. A binary logistic regression analysis was performed to further investigating the relation between having a concomitant CD with each BD manifestation and comorbidity, frequencies of which were detected to be significantly different in the student-test.
RESULTS
A total of 84,241 patients diagnosed with BS were analyzed, and CD was identified in 175 (0.21 %) patients. The group with CD had a mean age of 41.30 ± 13.69 which was significantly younger. the prevalence of females was significantly higher (71.4%). The mean age of first admission for BS was also significantly younger in the group with CD (36.64 ± 13.28). BS patients with CD had a significantly higher prevalence of inflammatory bowel disease (27.2% vs. 7.3%, p < 0.001). When comorbid conditions were investigated depression (35.4% vs. 23.3%, p < 0.001), migraine (7.4 % vs. 2.6%, p < 0.001), fibromyalgia (10.9% vs. 4.5%, p < 0.001) and osteoporosis (12.6% vs. 6.6%, p = 0.001) were significantly more frequent in BS patients with CD.
CONCLUSION
Our results suggest coexistence of CD in BS patients is related to female dominance and probably to an earlier disease onset. Several CD-related comorbidities as well as inflammatory bowel disease were more frequent in the CD group which implied an increased overall disease burden.
背景/目的：我们的主要目的是研究合并乳糜泻（CD）对贝切特综合征（BS）患者临床特征的影响。
材料和方法
该研究是一项回顾性的、全国性的、多中心研究。土耳其卫生部电子数据库（e-Nabız）在卫生部的监督下被用于提取受试者的数据。
统计学分析
统计分析由社会科学统计软件包（SPSS）版本 20（IBM 公司，纽约州阿蒙克）进行。连续变量根据正态性用平均值±标准差（SD）或中位数（最小值-最大值）表示，并通过学生 t 检验进行比较。采用二元逻辑回归分析进一步研究合并 CD 与每个 BS 表现和合并症之间的关系，学生检验发现这些表现和合并症的频率有显著差异。
结果
共分析了 84241 例诊断为 BS 的患者，其中 175 例（0.21%）患者合并 CD。CD 组的平均年龄为 41.30±13.69，明显较年轻。女性患病率明显较高（71.4%）。合并 CD 的 BS 患者首次入院时的平均年龄也明显较年轻（36.64±13.28）。BS 合并 CD 患者炎症性肠病的患病率显著较高（27.2% vs. 7.3%，p<0.001）。当研究合并症时，抑郁（35.4% vs. 23.3%，p<0.001）、偏头痛（7.4% vs. 2.6%，p<0.001）、纤维肌痛（10.9% vs. 4.5%，p<0.001）和骨质疏松症（12.6% vs. 6.6%，p=0.001）在 BS 合并 CD 患者中更为常见。
结论
我们的结果表明，BS 患者合并 CD 与女性优势有关，可能与疾病的早期发病有关。在 CD 组中，一些与 CD 相关的合并症以及炎症性肠病更为常见，这意味着整体疾病负担增加。
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