血清阳性多发性硬化症患者中抗转谷氨酰胺酶2和6抗体的患病率评估
Evaluation of the Prevalence of Anti-transglutaminase 2 and 6 Antibodies in Patients with Sero-Positive Multiple Sclerosis.
作者信息
Emami Mohammad Hassan, Najafi Mohammad Reza, Allahdadian Sepideh, Mohammadzadeh Samane, Jamali Nahid, Lalazarian Anasik, Shaygan Nejad Vahid, Maghool Fatemeh
机构信息
Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Pooya Zist-Mabna Hakim Company, Poursina Hakim Institute, Isfahan, Iran.
出版信息
Middle East J Dig Dis. 2024 Jan;16(1):47-51. doi: 10.34172/mejdd.2024.368. Epub 2024 Jan 31.
BACKGROUND
Gluten sensitivity (GS) is one of the gluten-related disorders (GRDs). Patients with GS may have serum antibodies against tissue transglutaminase (tTG) (IgA and IgG) without any evidence of enteropathy. We aimed to evaluate both tTG-6 and tTG-2 antibodies to determine the prevalence of seropositive tTG-2 and tTG-6 antibodies in patients with multiple sclerosis (MS).
METHODS
In this cross-sectional study, we carried out serological tests (IgA & IgG anti-tTG-6 and tTG-2 antibodies) in patients with MS.
RESULTS
Seventy-two patients with MS were included in this study. Of them, seropositive patients for total (IgA+IgG) of tTG-6 and tTG-2 autoantibodies were 9.7% (95% CI, 4.2-18) and 5.6% (95% CI, 1.4-12.5), respectively.
CONCLUSION
Anti-tTG-6 antibody testing may be necessary for early diagnosis of GS in patients with MS. More studies with larger sample sizes are warranted to confirm these data.
背景
麸质敏感性（GS）是麸质相关疾病（GRD）之一。GS患者可能有抗组织转谷氨酰胺酶（tTG）的血清抗体（IgA和IgG），但无任何肠病证据。我们旨在评估tTG-6和tTG-2抗体，以确定多发性硬化症（MS）患者中tTG-2和tTG-6抗体血清阳性的患病率。
方法
在这项横断面研究中，我们对MS患者进行了血清学检测（IgA和IgG抗tTG-6和tTG-2抗体）。
结果
本研究纳入了72例MS患者。其中，tTG-6和tTG-2自身抗体总（IgA+IgG）血清阳性患者分别为9.7%（95%CI，4.2-18）和5.6%（95%CI，1.4-12.5）。
结论
抗tTG-6抗体检测可能对MS患者GS的早期诊断有必要。需要更多样本量更大的研究来证实这些数据。
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