他汀类药物治疗对减少心外膜脂肪组织的疗效：一项系统评价和荟萃分析。
Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis.
作者信息
Jamialahmadi Tannaz, Simental-Mendia Luis E, Eid Ali H, Almahmeed Wael, Salehabadi Sepideh, Al-Rasadi Khalid, Banach Maciej, Sahebkar Amirhossein
机构信息
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Arch Med Sci. 2024 Jun 3;20(3):997-1001. doi: 10.5114/aoms/189575. eCollection 2024.
INTRODUCTION
Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.
METHODS
The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.
RESULTS
In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = -0.507, 95% CI: -2.536, 1.521, = 0.021).
CONCLUSIONS
Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
引言
了解他汀类药物对心外膜脂肪组织（EAT）的影响很重要，因为这可能有助于减少EAT衍生分子对心血管系统以及冠心病的负面影响。因此，我们旨在进行一项系统评价和荟萃分析，以评估他汀类药物治疗对EAT的影响。
方法
该研究利用Scopus、PubMed、Embase和Web of Science收集截至2023年9月5日关于他汀类药物对EAT影响的相关研究。使用综合荟萃分析（CMA）V4软件对收集的数据进行荟萃分析。
结果
在荟萃分析中，最终纳入了三项涉及512名受试者的研究。结果表明，他汀类药物治疗后EAT显著减少（标准化平均差（SMD）=-0.507，95%可信区间：-2.536，1.521，P=0.021）。
结论
他汀类药物似乎通过减少EAT发挥额外的心血管治疗作用。
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