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短段型先天性巨结肠症手术不做冰冻切片活检是否安全?60例病例综述

Is It Safe to Operate without Frozen Section Biopsies in Short-Segment Hirschsprung's Disease? An Overview of 60 Cases.

作者信息

Ademaj Isber, Hyseni Nexhmi, Gjonbalaj Naser

机构信息

Department of Pediatric Surgery, University Clinical Center of Kosovo, 10000 Pristina, Kosovo.

Department of Radiology, University Clinical Center of Kosovo, 10000 Pristina, Kosovo.

出版信息

Pediatr Rep. 2024 Jun 25;16(3):542-550. doi: 10.3390/pediatric16030045.

DOI:10.3390/pediatric16030045
PMID:39051232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270215/
Abstract

Advancements in surgical management in a single-stage procedure made intraoperative frozen section biopsies critical for determining of level of resection to avoid the potential risk of leaving a retained aganglionic segment. However, in most low-income countries, due to the lack of this facility, the surgeon's intraoperative judgment is used for the determination of the resection level. This study aims to evaluate the accuracy of determining the level of bowel resection in short-segment Hirschsprung's disease based on macroscopic changes. Intraoperative macroscopic evaluations were assessed using postoperative microscopic findings to determine whether the surgeons' intraoperative judgments were accurate in determining the level of bowel resection in 60 cases of operated short-segment Hirschsprung's disease. In addition, Pearson's correlation coefficient was used to determine whether the sensitivity and specificity of both methods were significantly correlated. The microscopic results showed that the level of resection based on the macroscopic evaluation was performed in normally ganglionated segment in cases of short-segment Hirschsprung's disease. Macroscopic intraoperative assessment by an experienced surgeon is highly accurate method of determining the level of bowel resection in short-segment HSCR.

摘要

在单阶段手术的外科治疗进展中,术中冰冻切片活检对于确定切除水平至关重要,以避免留下残留无神经节段的潜在风险。然而,在大多数低收入国家,由于缺乏这种设施,外科医生的术中判断用于确定切除水平。本研究旨在评估基于宏观变化确定短段型先天性巨结肠症肠切除水平的准确性。使用术后显微镜检查结果评估术中宏观评估,以确定60例接受手术的短段型先天性巨结肠症患者中,外科医生在确定肠切除水平时的术中判断是否准确。此外,使用皮尔逊相关系数来确定两种方法的敏感性和特异性是否显著相关。显微镜检查结果表明,在短段型先天性巨结肠症病例中,基于宏观评估的切除水平是在正常神经节化段进行的。经验丰富的外科医生进行的术中宏观评估是确定短段型先天性巨结肠症肠切除水平的高度准确的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd0e/11270215/68a7797893ab/pediatrrep-16-00045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd0e/11270215/68a7797893ab/pediatrrep-16-00045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd0e/11270215/68a7797893ab/pediatrrep-16-00045-g001.jpg

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本文引用的文献

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Determining the Correct Resection Level in Patients with Hirschsprung Disease Using Contrast Enema and Full Thickness Biopsies: Can the Diagnostic Accuracy be Improved by Examining Submucosal Nerve Fiber Thickness?应用对比灌肠和全层活检术判断先天性巨结肠症患者的正确切除平面:检测黏膜下神经纤维厚度能否提高诊断准确性?
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Hirschsprung disease managed with one-stage transanal endorectal pullthrough in a low-resource setting without frozen section.在资源匮乏的环境中,无需冰冻切片,通过经肛门直肠内拖出术一期治疗先天性巨结肠。
BMC Surg. 2022 Mar 8;22(1):89. doi: 10.1186/s12893-022-01536-9.
3
The Length of the Transition Zone in Patients with Rectosigmoid Hirschsprung Disease.
直肠乙状结肠型先天性巨结肠症患者过渡区的长度
Children (Basel). 2022 Jan 25;9(2):152. doi: 10.3390/children9020152.
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Histopathological perspective of the pulled-through colon in Hirschsprung disease: Impact on clinical outcome.先天性巨结肠经肛门拖出肠管的病理组织学观察:对临床转归的影响。
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The Extent of the Transition Zone in Hirschsprung Disease.先天性巨结肠症的移行区范围。
J Pediatr Surg. 2019 Nov;54(11):2318-2324. doi: 10.1016/j.jpedsurg.2019.04.017. Epub 2019 Apr 26.
8
Remodeling of Rectal Innervation After Pullthrough Surgery for Hirschsprung Disease: Relevance to Criteria for the Determination of Retained Transition Zone.先天性巨结肠拖出术后直肠神经重塑:与残留过渡区判定标准的相关性
Pediatr Dev Pathol. 2019 Jul-Aug;22(4):292-303. doi: 10.1177/1093526618817658. Epub 2018 Dec 12.
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European Paediatric Surgeons' Association Survey on the Management of Pediatric Appendicitis.欧洲小儿外科医生协会关于小儿阑尾炎治疗的调查
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