Department of Pediatrics, Shyam Shah Medical College, Rewa, Madhya Pradesh, India.
Department of Pediatrics, Shyam Shah Medical College, Rewa, Madhya Pradesh, India. Correspondence to: Dr Deepak Dwivedi, Department of Pediatrics, Shyam Shah Medical College, Rewa, Madhya Pradesh, India.
Indian Pediatr. 2024 Oct 15;61(10):935-940. Epub 2024 Jul 23.
To evaluate the change in the neurodevelopmental status of children (1-30-months-old) with severe acute malnutrition (SAM) following nutritional rehabilitation.
A prospective study was conducted in the Severe Malnutrition Therapeutic Unit (SMTU) of a tertiary hospital in Central India, between April 2021 and October 2022. Children with primary neurological conditions like cerebral palsy and epilepsy were excluded. Neurodevelopment was assessed using the Developmental Assessment Scale of Indian Infants (DASII) at admission and following nutritional rehabilitation as per the National Health Mission (NHM) guidelines at the time of discharge, 2 months and 4 months follow-up. Developmental quotient (DQ) ≤ 70 was considered delayed.
114 children with SAM were included; 4 were lost to follow-up. There was an increase in Motor Developmental Quotient (MoDQ) and Mental Developmental Quotient (MeDQ) at discharge, 2 months, and 4 months. The improvement in MoDQ and MeDQ was greater in children with adequate weight gain. Poor weight gain, higher age of presentation and lower MeDQ and MoDQ at admission were associated with persistent developmental delay at 4 months follow-up.
There was a consistent improvement in DQ with improvement in nutritional status.
评估严重急性营养不良（SAM）儿童（1-30 月龄）在营养康复后的神经发育状况变化。
本前瞻性研究于 2021 年 4 月至 2022 年 10 月在印度中部一家三级医院的严重营养不良治疗单位（SMTU）进行。排除有脑瘫和癫痫等原发性神经疾病的儿童。在入院时和根据国家卫生使命（NHM）指南在出院时、2 个月和 4 个月随访时使用印度婴儿发育评估量表（DASII）评估神经发育。发育商（DQ）≤70 被认为是发育迟缓。
共纳入 114 例 SAM 患儿，4 例失访。出院时、2 个月和 4 个月时，运动发育商（MoDQ）和精神发育商（MeDQ）均增加。体重增长充足的儿童的 MoDQ 和 MeDQ 改善更大。体重增长不良、就诊年龄较高以及入院时 MeDQ 和 MoDQ 较低与 4 个月随访时持续发育迟缓有关。
随着营养状况的改善，DQ 持续改善。
