Miura-Takahashi Erika, Tashiro Kohei, Shiga Yuhei, Kawahira Yuto, Higashi Sara, Otsu Yuki, Kamimura Hidetoshi, Miura Shin-Ichiro
Department of Pharmacy, Fukuoka University Hospital, Fukuoka 814-0180, Japan.
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Pharmacy (Basel). 2024 Jun 27;12(4):99. doi: 10.3390/pharmacy12040099.
Because patients often already have coronary artery disease (CAD) at the time of a coronary artery computed tomography angiography (CCTA) examination, we examined the medications prescribed by medical doctors for lifestyle-related diseases and investigated what possible role pharmacists can play in prescribing.
Patients (n = 1357) who underwent CCTA examination were divided into two groups according to the presence or absence of lifestyle-related diseases [hypertension (HTN), dyslipidemia (DL) and diabetes mellitus (DM)], and the relationship between the presence or absence of CAD was examined.
The rate of CAD was significantly higher in patients with HTN, DL or DM than in patients without these diseases. The blood pressure in the HTN group was 140 ± 20/79 ± 13 mmHg, the low-density lipoprotein cholesterol value in the DL group was 119 ± 35 mg/dL, and the hemoglobin A1c value in the DM group was 7.0 ± 1.1%, all of which were poorly controlled. Anti-hypertensive drugs were used at low rates in the HTN group, statins were used in 47% and ezetimibe was used in 4% of the DL group, and dipeptidyl peptidase-4 inhibitors were used in 41% of the DM group.
Since the rate of CAD (+) was high and control of the three major lifestyle-related diseases was poor, pharmacists should advise medical doctors to use combinations of drugs.
由于患者在进行冠状动脉计算机断层扫描血管造影（CCTA）检查时通常已经患有冠状动脉疾病（CAD），我们检查了医生为生活方式相关疾病所开的药物，并调查了药剂师在开药过程中可能发挥的作用。
对接受CCTA检查的患者（n = 1357），根据是否患有生活方式相关疾病[高血压（HTN）、血脂异常（DL）和糖尿病（DM）]分为两组，并检查CAD的有无之间的关系。
患有HTN、DL或DM的患者中CAD的发生率显著高于没有这些疾病的患者。HTN组的血压为140±20/79±13 mmHg，DL组的低密度脂蛋白胆固醇值为119±35 mg/dL，DM组的糖化血红蛋白值为7.0±1.1%，所有这些指标的控制情况都很差。HTN组使用抗高血压药物的比例较低，DL组47%使用他汀类药物，4%使用依折麦布，DM组41%使用二肽基肽酶-4抑制剂。
由于CAD（+）的发生率很高，且三种主要生活方式相关疾病的控制情况较差，药剂师应建议医生联合用药。
