Stains Elena Lynn, Patel Akshay C, Solgama Jay P, Hagedorn Joseph D, McCall Kenneth L, Piper Brian J
Department of Medical Education, Geisinger Commonwealth School of Medicine, Scranton, PA 18510, USA.
Jefferson Einstein Hospital, Philadelphia, PA 19141, USA.
Pharmacy (Basel). 2024 Jun 28;12(4):102. doi: 10.3390/pharmacy12040102.
Florida, which led the country in terms of its number of opioid-prescribing physicians, was unique during the height of the opioid epidemic because of its lax prescribing laws and high number of unregulated pain clinics. Here, we address differences in the distribution rates of oxycodone and hydrocodone across Florida counties during the peak years of the opioid epidemic using an under-utilized database.
The Washington Post and the United States Drug Enforcement Administration's Automation of Reports and Consolidated Orders System (ARCOS) databases provided longitudinal oxycodone and hydrocodone distribution data in grams per county (2006-2014) and state (2006-2021). Grams of oxycodone and hydrocodone were converted into morphine milligram equivalents (MMEs).
There was a steep increase in oxycodone from 2006 to 2010, with a subsequent decline. In 2010, the average MME per person across Florida was 729.4, a 120.6% increase from 2006. The three counties with the highest MMEs per person in 2010 were Hillsborough (2271.3), Hernando (1915.3), and Broward (1726.9), and they were significantly ( < 0.05) elevated relative to the average county.
The data demonstrated pronounced differences in opioid distribution, particularly oxycodone, between Florida counties during the height of the opioid epidemic. Legislative action taken between 2009 and 2011 aligns with the considerable decline in opioid distribution after 2010.
佛罗里达州的阿片类药物处方医生数量位居美国之首，在阿片类药物流行高峰期，该州因宽松的处方法律和大量不受监管的疼痛诊所而独具特色。在此，我们利用一个未得到充分利用的数据库，探讨阿片类药物流行高峰期佛罗里达州各县羟考酮和氢可酮的分发率差异。
《华盛顿邮报》和美国缉毒局的报告与综合命令系统自动化（ARCOS）数据库提供了各县（2006 - 2014年）和全州（2006 - 2021年）以克为单位的羟考酮和氢可酮纵向分发数据。羟考酮和氢可酮的克数被换算成吗啡毫克当量（MME）。
2006年至2010年羟考酮急剧增加，随后下降。2010年，佛罗里达州人均MME为729.4，比2006年增长了120.6%。2010年人均MME最高的三个县是希尔斯伯勒（2271.3）、赫尔南多（1915.3）和布劳沃德（1726.9），它们相对于平均水平显著升高（<0.05）。
数据表明，在阿片类药物流行高峰期，佛罗里达州各县之间的阿片类药物分发存在显著差异，尤其是羟考酮。2009年至2011年采取的立法行动与2010年后阿片类药物分发的大幅下降相一致。
