Tursi Antonio, Mocci Giammarco, Satta Paolo Usai, Elisei Walter
Department of Territorial Gastroenterology Service, ASL BAT, Andria (BT), Italy.
Department of Medical and Surgical Sciences, School of Medicine, Catholic University, Rome, Italy.
Rev Recent Clin Trials. 2025;20(1):27-35. doi: 10.2174/0115748871308652240712101604.
Microbial imbalance is thought to play a role in the pathogenesis of Diverticular Disease (DD).
We aimed to assess the efficacy of a symbiotic mixture () in the treatment of moderate to severe DD, scored according to the Diverticular Inflammation and Complication Assessment (DICA) classification.
A retrospective study was conducted enrolling the following patients: at the first diagnosis of DD; in whom DD was diagnosed with colonoscopy and scored according to DICA classification; treated with two times/daily for 2 consecutive months; in whom the severity of the abdominal pain was scored with a 10-points visual-analogue scale (VAS) at baseline and the end of follow-up; in whom fecal calprotectin (FC) was assessed at baseline and the end of follow-up as μg/g.
Twenty-four patients were identified (10 males, 14 females; 16 as DICA 2, and 8 as DICA 3). decreased the severity of abdominal pain both in DICA 2 (p =0.02) and DICA 3 patients (p =0.01), while FC decreased significantly in DICA 2 (p <0.02) but not in DICA 3 (p =0.123) patients. Acute diverticulitis occurred during the follow-up in two DICA 3 patients but none DICA 2 patients. Add-on therapy was required by eight DICA 2 (50%) and six DICA 3 patients (75%).
In newly diagnosed patients with DD, the symbiotic mixture can be a potential treatment for moderate (DICA 2) DD as a single treatment.
微生物失衡被认为在憩室病（DD）的发病机制中起作用。
我们旨在评估一种共生混合物（）对根据憩室炎和并发症评估（DICA）分类评分的中重度DD的治疗效果。
进行了一项回顾性研究，纳入以下患者：首次诊断为DD；经结肠镜检查诊断为DD并根据DICA分类评分；每天两次服用 ，连续服用2个月；在基线和随访结束时用10分视觉模拟量表（VAS）对腹痛严重程度进行评分；在基线和随访结束时评估粪便钙卫蛋白（FC），单位为μg/g。
共纳入24例患者（男性10例，女性14例；16例为DICA 2，8例为DICA 3）。在DICA 2（p =0.02）和DICA 3患者（p =0.01）中均降低了腹痛的严重程度，而FC在DICA 2患者中显著降低（p <0.02），但在DICA 3患者中未显著降低（p =0.123）。在随访期间，两名DICA 3患者发生了急性憩室炎，但DICA 2患者均未发生。8例DICA 2（50%）和6例DICA 3患者（75%）需要追加治疗。
在新诊断的DD患者中，共生混合物 作为单一治疗方法可能是中度（DICA 2）DD的一种潜在治疗方法。
