炎症性肠病患者患小肠癌的风险：一项来自美国大型多中心数据库的倾向匹配研究
Risk of Small Intestine Cancer in Inflammatory Bowel Disease: A Propensity-Matched Study from a Large Multi-Center Database in the United States.
作者信息
Alsakarneh Saqr, Ahmed Mohamed, Azim Samiya, Hashash Jana G, Farraye Francis A, Ghoz Hassan
机构信息
Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.
Department of Gastroenterology and Hepatology, University of Missouri-Kansas City, Kansas City, MO, USA.
出版信息
Am J Gastroenterol. 2024 Jul 25. doi: 10.14309/ajg.0000000000002984.
INTRODUCTION
The risk of small bowel cancer (SBC) in inflammatory bowel disease (IBD) is unclear. We compared the recent trends of SBC in patients with IBD and stratified them based on disease type.
METHODS
We used TriNetX database to access the electronic health records for patients with IBD, ulcerative colitis (UC) and Crohn's disease (CD) from 2005-2024. We used propensity score matching to compare the rate of SBC in patients with IBD, UC, and CD compared to the general population. We adjusted for all known confounders.
RESULTS
From 2010-2024, there was an increasing trend of diagnosed SBC in patients with IBD, with an Average Annual Percentage Change (AAPC) of 3.2% (P<0.001). Patients with CD (aHR = 4.83; 95% CI: 3.58 - 6.53; P < .0001) had an increased risk of SBC compared to the general population without IBD, as well as patients with UC (aHR = 2.28; 95% CI: 1.65 - 3.14; P < .0001). The ileum was the most common location across all subgroups.
CONCLUSION
Both patients with CD and, interestingly, UC had an elevated risk for developing SBC compared to the general population.
引言
炎症性肠病（IBD）患者患小肠癌（SBC）的风险尚不清楚。我们比较了IBD患者中SBC的近期趋势，并根据疾病类型对其进行了分层。
方法
我们使用TriNetX数据库获取2005年至2024年IBD、溃疡性结肠炎（UC）和克罗恩病（CD）患者的电子健康记录。我们使用倾向评分匹配法比较IBD、UC和CD患者与普通人群中SBC的发病率。我们对所有已知的混杂因素进行了调整。
结果
从2010年到2024年，IBD患者中确诊SBC的趋势呈上升趋势，平均年百分比变化（AAPC）为3.2%（P<0.001）。与无IBD的普通人群以及UC患者相比，CD患者（aHR = 4.83；95% CI：3.58 - 6.53；P <.0001）患SBC的风险增加。在所有亚组中，回肠是最常见的发病部位。
结论
与普通人群相比，CD患者以及有趣的是UC患者患SBC的风险均升高。
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