Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Neurology, the Marlene and Paolo Fresco Institute for Parkinson's Disease and Movement Disorders, New York University Langone Health, New York, New York, USA.
Mov Disord. 2024 Nov;39(11):2091-2097. doi: 10.1002/mds.29937. Epub 2024 Jul 25.
Elevated levels of prokineticin-2 (PK2), regarded as a protein involved in modulating immune/inflammatory responses, have been detected in the substantia nigra, serum, and olfactory neurons of Parkinson's disease (PD) patients. Of note, emerging evidence suggests that gut alterations, including dysbiosis and enteric inflammation, play a role in PD via the gut-brain axis.
Our goal was to investigate the expression of PK2 in colonic biopsies of PD patients.
Mucosal biopsies from the descending colon were obtained in 11 PD patients and five asymptomatic subjects. Biopsy samples were processed for PK2 immunofluorescence and western blot.
We revealed an increased PK2 expression in colonic mucosa from PD patients in the early stages compared to controls. In addition, we found that PK2 was expressed by activated enteric glial cells and macrophages.
PK2 is highly expressed within neurogenic/inflammatory cells of colonic mucosa from early PD patients, suggesting a potential role of PK2 in gut inflammation, especially in the early stages of PD. © 2024 International Parkinson and Movement Disorder Society.
促动力素 2（PK2）水平升高被认为是参与调节免疫/炎症反应的一种蛋白，已在帕金森病（PD）患者的黑质、血清和嗅神经元中检测到。值得注意的是，新出现的证据表明，肠道改变，包括肠道菌群失调和肠道炎症，通过肠道-大脑轴在 PD 中发挥作用。
我们的目的是研究 PK2 在 PD 患者结肠活检中的表达。
从 11 例 PD 患者和 5 例无症状受试者的降结肠获得黏膜活检。对活检样本进行 PK2 免疫荧光和 Western blot 处理。
与对照组相比，我们发现早期 PD 患者结肠黏膜中 PK2 的表达增加。此外，我们发现 PK2 由活化的肠胶质细胞和巨噬细胞表达。
PK2 在早期 PD 患者结肠黏膜的神经源性/炎症细胞中高度表达，提示 PK2 可能在肠道炎症中发挥作用，尤其是在 PD 的早期阶段。© 2024 国际帕金森病和运动障碍学会。
