Ben-Mussa Ali, Shah Rajeev, Rajendran Simon, McCluggage W Glenn
Department of Pathology, Western Health and Social Care Trust, Londonderry, Northern Ireland, United Kingdom.
Department of Pathology, Southern Health and Social Care Trust, Craigavon, Northern Ireland, United Kingdom.
Int J Gynecol Pathol. 2025 May 1;44(3):249-254. doi: 10.1097/PGP.0000000000001063. Epub 2024 Jul 22.
Cervical adenocarcinomas are now classified as human papillomavirus (HPV)-associated and HPV-independent types with the former being more common. However, population-based studies regarding the relative incidences of the 2 types are few. This study investigates the incidence of cervical adenocarcinomas in Northern Ireland (a country with a relatively stable population of ~1.8 million) over a recent 9-year period (2015-2023). Overall, there were 146 primary cervical adenocarcinomas, 130 HPV-associated (89%) and 16 HPV-independent (11%). The median age was 43 years (range: 24-82) for HPV-associated and 62.5 years (range: 31-84) for HPV-independent neoplasms; this was statistically significant ( P < 0.001). The calculated age-adjusted incidence of the patients with HPV-associated and HPV-independent neoplasms was 1.68 and 0.20 per 100,000 person-years, respectively. The HPV-independent neoplasms were more often advanced stage at diagnosis; 97 of 130 (75.4%) of the HPV-associated cases were diagnosed at Stage I compared with 5 of 16 (31.3%) of the HPV-independent cases. The HPV-independent neoplasms were mostly gastric-type (56.3%) with smaller numbers of clear cells and mesonephric. Despite the relatively short follow-up, the mortality of patients with HPV-independent adenocarcinomas was significantly higher than patients with HPV-associated neoplasms (56.3% vs 5.4%) with a median survival of just over a year (13.2 mo) in the former for those who died.
宫颈腺癌现分为人乳头瘤病毒（HPV）相关型和HPV非相关型，前者更为常见。然而，关于这两种类型相对发病率的基于人群的研究较少。本研究调查了北爱尔兰（一个人口相对稳定，约180万的地区）在最近9年期间（2015 - 2023年）宫颈腺癌的发病率。总体而言，共有146例原发性宫颈腺癌，其中130例为HPV相关型（89%），16例为HPV非相关型（11%）。HPV相关型肿瘤的中位年龄为43岁（范围：24 - 82岁），HPV非相关型肿瘤的中位年龄为62.5岁（范围：31 - 84岁）；这具有统计学意义（P < 0.001）。HPV相关型和HPV非相关型肿瘤患者经年龄调整后的发病率分别为每10万人年1.68例和0.20例。HPV非相关型肿瘤在诊断时更常处于晚期；130例HPV相关病例中有97例（75.4%）在I期被诊断，而16例HPV非相关病例中有5例（31.3%）在I期被诊断。HPV非相关型肿瘤大多为胃型（56.3%），透明细胞型和中肾型数量较少。尽管随访时间相对较短，但HPV非相关型腺癌患者的死亡率显著高于HPV相关型肿瘤患者（56.3%对5.4%），前者死亡患者的中位生存期略超过一年（13.2个月）。
