International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch, Lyon, France.
Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
J Infect Dis. 2024 Jul 25;230(1):55-60. doi: 10.1093/infdis/jiad506.
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.
我们评估了在 ANRS-EP57-APACHES 研究中，410 名接受人免疫缺陷病毒（HIV）感染的男男性行为者（MSM），在 2 年内进行了 3 次随访，每次随访均进行细胞学和高分辨率肛门镜检查，分析累积检测到肛门高级别鳞状上皮内病变（HSIL）的情况及其影响因素。累积 HSIL 检出率为 33%（410 名中的 134 名），其中 48%的 HSIL 是在基线时检出的。HSIL 的检出率因中心而异（从 13%到 51%）。最强的 HSIL 决定因素是基线时的人乳头瘤病毒 16（调整后的优势比，8.2；95%置信区间，3.6-18.9）和 p16/Ki67（4.6 [2.3-9.1]）。重复的年度细胞学和高分辨率肛门镜检查提高了 HSIL 的检出率，但未能完全弥补中心间的异质性。
