阿替洛尔对血压及心脏β受体阻滞程度的剂量反应。
Dose response for blood pressure and degree of cardiac beta-blockade with atenolol.
作者信息
Marshall A J, Barritt D W, Heaton S, Harry J D
出版信息
Postgrad Med J. 1979 Sep;55(646):537-40. doi: 10.1136/pgmj.55.646.537.
Abstract
The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.
摘要
在一项双盲患者自身对照研究中，比较了每日服用25毫克、50毫克、75毫克、100毫克阿替洛尔及不服用阿替洛尔（0毫克）的降压效果。每日服用25毫克时的血压下降幅度与服用100毫克时相比无显著差异。剂量反应曲线处于每日0至25毫克之间。每日服用25毫克阿替洛尔时，心脏β受体阻滞作用（通过抑制运动性心动过速来衡量）未达到最大值。β受体阻滞作用和降压效果的剂量反应曲线不平行。
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