Departments of Pediatrics.
Pathology, Dokuz Eylül University Medical Faculty.
J Pediatr Hematol Oncol. 2024 Oct 1;46(7):e534-e536. doi: 10.1097/MPH.0000000000002931. Epub 2024 Jul 25.
Immune checkpoint inhibitors are humanized antibodies that inhibit downregulatory receptors on T cells, enhancing the antitumor activity of these cells. However, they have been associated with a wide range of systemic immune-related adverse events, including renal toxicities, among others. Most renal immune-related adverse events are acute interstitial nephritis causing acute kidney injury. Recently, immune checkpoint inhibitors-associated glomerular diseases, including IgA nephropathy, have been reported in adults. Most of the adult cases with glomerular involvement had also concomitant acute interstitial nephritis and acute kidney injury. We present the first pediatric case of IgA nephropathy without acute kidney injury during nivolumab treatment.
免疫检查点抑制剂是一种人源化抗体，可抑制 T 细胞上的下调受体，增强这些细胞的抗肿瘤活性。然而，它们与广泛的全身性免疫相关不良事件相关，包括肾毒性等。大多数肾免疫相关不良事件是导致急性肾损伤的急性间质性肾炎。最近，在成人中报告了与免疫检查点抑制剂相关的肾小球疾病，包括 IgA 肾病。大多数伴有肾小球受累的成人病例也同时伴有急性间质性肾炎和急性肾损伤。我们报告了首例在纳武单抗治疗期间发生 IgA 肾病而无急性肾损伤的儿科病例。
