Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
Pathol Res Pract. 2024 Aug;260:155462. doi: 10.1016/j.prp.2024.155462. Epub 2024 Jul 14.
Lipoleiomyomas are rare variants of uterine leiomyomas rarely studied in the literature. We retrospectively studied 20 cases of uterine lipoleiomyomas showing that these lesions represent 0.7 % of all uterine leiomyomas diagnosed histologically. The patients did not experience any recurrence, and the tumors showed no morphological criteria of malignancy. They did not show significant p16, p53 or MiB1 expression. They showed diffuse and strong expression or estrogen and progesterone receptors by the smooth muscle component but without accompanying expression by the adipocytic component in one third of the cases. Androgen receptors were rarely expressed. They expressed in their majority HMGA2 in both components, while RB1 was usually not found. Fumarate hydratase (FH) is expressed by lipoleiomyomas, while they are negative for HMB45. In conclusion, uterine lipoleiomyomas are rare, benign tumors, characterized by HMGA2 expression, while they show no elements suspicious of malignancy, PEComas or FH deficiency. The role of RB1 in these tumors should be further explored.
脂肪平滑肌瘤是子宫平滑肌瘤的罕见变异型，在文献中研究甚少。我们回顾性研究了 20 例子宫脂肪平滑肌瘤，这些病变占组织学诊断的所有子宫平滑肌瘤的 0.7%。患者无复发，肿瘤无恶性形态学标准。它们不表达 p16、p53 或 MiB1。在三分之一的病例中，平滑肌成分弥漫且强烈表达雌激素和孕激素受体，但脂肪成分不伴表达。雄激素受体很少表达。它们在两个成分中均大量表达 HMGA2，而 RB1 通常不表达。富马酸水合酶 (FH) 在脂肪平滑肌瘤中表达，而它们对 HMB45 呈阴性。总之，子宫脂肪平滑肌瘤是罕见的良性肿瘤，其特征是 HMGA2 表达，而没有恶性、PEComa 或 FH 缺乏的元素。RB1 在这些肿瘤中的作用应进一步探讨。
