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一种用于骨盆骨折手术规划中骨折模拟和基于变形的修复预测的双向框架。

A bidirectional framework for fracture simulation and deformation-based restoration prediction in pelvic fracture surgical planning.

机构信息

Institute of Biomedical Manufacturing and Life Quality Engineering, School of Mechanical Engineering, Shanghai Jiao Tong University, China.

Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Med Image Anal. 2024 Oct;97:103267. doi: 10.1016/j.media.2024.103267. Epub 2024 Jul 10.

Abstract

Pelvic fracture is a severe trauma with life-threatening implications. Surgical reduction is essential for restoring the anatomical structure and functional integrity of the pelvis, requiring accurate preoperative planning. However, the complexity of pelvic fractures and limited data availability necessitate labor-intensive manual corrections in a clinical setting. We describe in this paper a novel bidirectional framework for automatic pelvic fracture surgical planning based on fracture simulation and structure restoration. Our fracture simulation method accounts for patient-specific pelvic structures, bone density information, and the randomness of fractures, enabling the generation of various types of fracture cases from healthy pelvises. Based on these features and on adversarial learning, we develop a novel structure restoration network to predict the deformation mapping in CT images before and after a fracture for the precise structural reconstruction of any fracture. Furthermore, a self-supervised strategy based on pelvic anatomical symmetry priors is developed to optimize the details of the restored pelvic structure. Finally, the restored pelvis is used as a template to generate a surgical reduction plan in which the fragments are repositioned in an efficient jigsaw puzzle registration manner. Extensive experiments on simulated and clinical datasets, including scans with metal artifacts, show that our method achieves good accuracy and robustness: a mean SSIM of 90.7% for restorations, with translational errors of 2.88 mm and rotational errors of 3.18°for reductions in real datasets. Our method takes 52.9 s to complete the surgical planning in the phantom study, representing a significant acceleration compared to standard clinical workflows. Our method may facilitate effective surgical planning for pelvic fractures tailored to individual patients in clinical settings.

摘要

骨盆骨折是一种严重的创伤,可能危及生命。手术复位对于恢复骨盆的解剖结构和功能完整性至关重要,需要进行准确的术前规划。然而,骨盆骨折的复杂性和有限的数据可用性需要在临床环境中进行繁琐的手动校正。我们在本文中描述了一种基于骨折模拟和结构恢复的自动骨盆骨折手术规划的新的双向框架。我们的骨折模拟方法考虑了患者特定的骨盆结构、骨密度信息和骨折的随机性,能够从健康的骨盆中生成各种类型的骨折病例。基于这些特征和对抗学习,我们开发了一种新的结构恢复网络,用于预测骨折前后 CT 图像中的变形映射,以便对任何骨折进行精确的结构重建。此外,还开发了一种基于骨盆解剖对称性先验的自监督策略,以优化恢复的骨盆结构的细节。最后,将恢复的骨盆用作模板,以生成手术复位计划,其中通过高效的拼图注册方式重新定位碎片。在模拟和临床数据集(包括带有金属伪影的扫描)上进行的广泛实验表明,我们的方法具有良好的准确性和鲁棒性:在真实数据集的重建中,平均 SSIM 为 90.7%,平移误差为 2.88mm,旋转误差为 3.18°。在幻影研究中,我们的方法完成手术规划需要 52.9 秒,与标准临床工作流程相比有了显著的加速。我们的方法可以促进针对临床环境中个体患者的骨盆骨折的有效手术规划。

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