Mosienko V S, Zagoruĭko L I, Todor I N
Eksp Onkol. 1985;7(5):8-14.
The data available in literature and results of the authors, own investigations on the oxygen metabolism during the appearance and development of the tumour process are presented. The important role of biological oxidation disorders in cell malignancy is discussed. The appearance and development of malignant tumours occur against a background of tissues hypoxia. Severe hypoxia and anoxia are observed constantly in the tumour tissue. Some mechanisms of hypoxia development and cell respiration reduction in malignant tumours are considered. Necessity of methods and drugs searching (antihypoxic agents and antioxidants) for correction of oxygen homeostasis disturbances and increase of antitumour resistance of the organism is substantiated.
本文介绍了文献中的现有数据以及作者自己对肿瘤发生发展过程中氧代谢的研究结果。讨论了生物氧化紊乱在细胞恶性肿瘤中的重要作用。恶性肿瘤的发生发展是在组织缺氧的背景下发生的。在肿瘤组织中经常观察到严重的缺氧和无氧状态。考虑了恶性肿瘤中缺氧发展和细胞呼吸减少的一些机制。证实了寻找方法和药物（抗缺氧剂和抗氧化剂）以纠正氧稳态紊乱并提高机体抗肿瘤抵抗力的必要性。
