Bava Davood, Panda Samhita, Jain Romesh, Mittal Siddharth, Gupta Anubhav, Khan Atik, Mandal Saptarshi, Bajpayee Archana
Department of IHBT, NIMS Jaipur, Jaipur, India.
Department of Neurology, AIIMS Jodhpur, Jodhpur, India.
Ther Apher Dial. 2025 Feb;29(1):114-122. doi: 10.1111/1744-9987.14189. Epub 2024 Jul 25.
Autoimmune neurological diseases (ANDs) involve the immune system attacking the nervous system, leading to various symptoms. Therapeutic plasma exchange (TPE) is used to remove pathogenic autoantibodies, aiming to improve clinical outcomes.
This ambispective observational study included 99 patients with ANDs who underwent TPE from January 2018 to June 2022 at a tertiary care center in India. Clinical outcomes were measured using the modified Rankin Scale (mRS) scores at admission, post-TPE, at 3-months, 6-months, and 1-year follow-up post-discharge. Data were analyzed using Epi Info version 7.0.
The median mRS score improved significantly from 5 (IQR 4-5) before TPE to 3 (IQR 2-4) post-TPE (p < 0.001). Complications occurred in 5.95% of procedures, with allergic reactions being the most common. The in-hospital mortality rate was 9%.
TPE is a safe and effective treatment modality for autoimmune neurological diseases, especially in resource-constrained settings. It aids in both symptomatic relief and reducing long-term functional disability.
自身免疫性神经疾病（ANDs）涉及免疫系统攻击神经系统，导致各种症状。治疗性血浆置换（TPE）用于清除致病性自身抗体，旨在改善临床结局。
这项双向观察性研究纳入了99例2018年1月至2022年6月在印度一家三级医疗中心接受TPE的ANDs患者。使用改良Rankin量表（mRS）评分在入院时、TPE后、出院后3个月、6个月和1年随访时测量临床结局。使用Epi Info 7.0版本分析数据。
mRS评分中位数从TPE前的5（四分位间距4 - 5）显著改善至TPE后的3（四分位间距2 - 4）（p < 0.001）。5.95%的操作发生并发症，过敏反应最为常见。住院死亡率为9%。
TPE是自身免疫性神经疾病的一种安全有效的治疗方式，尤其是在资源有限的环境中。它有助于缓解症状并减少长期功能残疾。
