Emory University School of Medicine, Emory Center for Ethics, Emory University, 200 Dowman Drive, Atlanta, GA 30322, USA.
Anesthesiol Clin. 2024 Sep;42(3):445-455. doi: 10.1016/j.anclin.2023.12.001. Epub 2023 Dec 16.
Drug shortages remain a serious and widespread problem affecting all health systems and patients. Anesthesiology practice is strongly impacted by shortages of sterile injectable drugs, resulting in a negative impact on the quality of care. Understanding the root causes of drug shortages guides the anesthesiologist toward an ethical response. While rationing is a common consideration in secular ethics, and indeed rationing strategies are utilized, the use of rationing alone risks normalizing and perpetuating the drug shortage problem. Drug shortages are the direct result of a market failure brought on by lack of oversight of drug production standards in some cases as well as by the impact of intermediary purchasing groups on costs and availability of drugs. Legislation needs to reestablish a responsible, competitive, and robust manufacturing drug market.
药物短缺仍然是一个严重且普遍的问题,影响着所有的医疗体系和患者。麻醉学实践受到无菌注射药物短缺的严重影响,导致医疗质量受到负面影响。了解药物短缺的根本原因可以引导麻醉师做出合乎伦理的回应。虽然配给在世俗伦理中是一个常见的考虑因素,而且实际上也在使用配给策略,但仅使用配给有使药物短缺问题正常化和永久化的风险。药物短缺是市场失灵的直接结果,在某些情况下,药物生产标准缺乏监管,以及中间商采购团体对药物成本和供应的影响,都导致了这一结果。立法需要重新建立一个负责任、有竞争力和强大的制药市场。