Pogledic Ivana, Mankad Kshitij, Severino Mariasavina, Lerman-Sagie Tally, Jakab Andras, Hadi Efrat, Jansen Anna C, Bahi-Buisson Nadia, Di Donato Natalya, Oegema Renske, Mitter Christian, Capo Ivan, Whitehead Matthew T, Haldipur Parthiv, Mancini Grazia, Huisman Thierry A G M, Righini Andrea, Dobyns Bill, Barkovich James A, Milosevic Natasa Jovanov, Kasprian Gregor, Lequin Maarten
Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N3JH, UK.
Brain. 2024 Dec 3;147(12):3982-4002. doi: 10.1093/brain/awae253.
Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as well as further insights from post-mortem imaging, has been highlighted.
脑畸形代表了一组异质性的神经形态发生异常，常与神经元连接和脑容量异常相关。产前检测脑畸形需要通过妊娠的各个阶段清晰了解胚胎学和发育形态学。撰写本专家小组综述的主要目的是，基于目前对正常和异常脑发育的理解，提供一份易于理解的路线图，以改善产前对结构畸形的检测和特征描述。对于每个发育阶段，都着重介绍了每种可用神经成像模态的效用，包括产前多平面神经超声检查、解剖磁共振成像和先进的磁共振成像技术，以及尸检成像的进一步见解。
