Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Ann Clin Transl Neurol. 2024 Aug;11(8):2166-2175. doi: 10.1002/acn3.52137. Epub 2024 Jul 25.
Global brain volume changes in patients with myelin oligodendrocyte glycoprotein antibody-associated disease compared with healthy controls (HC) could be revealed by magnetic resonance imaging, but specific atrophy patterns of cortical structures and relation to cognitive impairment are not yet comprehensively known. Thus, we aimed to investigate cortical thickness differences in patients with myelin oligodendrocyte glycoprotein antibody-associated disease compared with HC.
3-Tesla brain magnetic resonance imaging was performed in 23 patients with myelin oligodendrocyte glycoprotein antibody-associated disease and 49 HC for voxel-wise group comparisons and neuropsychological testing in patients. Surface-based morphometry with region of interest-based surface analysis and region of interest-based extraction of cortical thickness was performed in patients compared with HC and in patient subgroups with and without cognitive impairment.
Comparing patients with myelin oligodendrocyte glycoprotein antibody-associated disease with HC, exploratory surface-based morphometry demonstrated cortical volume reduction in pericalcarine and lingual cortical regions. Region of interest-based surface analysis specified reduced cortical thickness in the adjacent pericalcarine and orbitofrontal regions in myelin oligodendrocyte glycoprotein antibody-associated disease, as well as reduced temporal cortical thickness in patients with cognitive impairment (n = 10). Patients without cognitive impairment (n = 13) showed only circumscribed cortical brain volume loss compared with HC in the pericalcarine region.
In conclusion, cortical atrophy in myelin oligodendrocyte glycoprotein antibody-associated disease was characterized by cortical thickness reduction in the adjacent pericalcarine and orbitofrontal regions, with a tendency of temporal thickness reduction in cognitively impaired patients.
通过磁共振成像（MRI）可以揭示髓鞘少突胶质细胞糖蛋白抗体相关疾病患者的全球脑容量变化，但皮质结构的具体萎缩模式及其与认知障碍的关系尚不清楚。因此，我们旨在研究髓鞘少突胶质细胞糖蛋白抗体相关疾病患者与健康对照组（HC）之间的皮质厚度差异。
对 23 例髓鞘少突胶质细胞糖蛋白抗体相关疾病患者和 49 例 HC 进行了 3T 脑部 MRI 检查，以进行体素-wise 组比较和对患者进行神经心理学测试。在患者中与 HC 进行了基于体素的形态计量学和基于感兴趣区的皮质厚度提取的皮质厚度比较，并在患者亚组中进行了基于感兴趣区的皮质厚度比较，该亚组包括有认知障碍和无认知障碍的患者。
将髓鞘少突胶质细胞糖蛋白抗体相关疾病患者与 HC 进行比较，探索性基于体素的形态计量学显示在距状回和舌回皮质区域存在皮质体积减少。基于感兴趣区的表面分析表明，在髓鞘少突胶质细胞糖蛋白抗体相关疾病中，相邻的距状回和眶额回皮质厚度降低，以及认知障碍患者的颞叶皮质厚度降低（n=10）。无认知障碍的患者（n=13）与 HC 相比，仅在距状回区域显示局限性皮质脑容量减少。
髓鞘少突胶质细胞糖蛋白抗体相关疾病的皮质萎缩表现为相邻距状回和眶额回皮质厚度的减少，在认知障碍患者中存在颞叶厚度减少的趋势。
