如我们过去和应然那样，对精神分裂症成人进行联合运动训练：皮质-精神分裂症研究第二部分。

As We Were and As We Should Be, Combined Exercise Training in Adults With Schizophrenia: CORTEX-SP Study Part II.

机构信息

Society, Sports, and Physical Exercise Research Group, GIzartea, Kirola eta Ariketa Fisikoa Ikerkuntza Taldea (GIKAFIT), Department of Physical Education and Sport, Faculty of Education and Sport-Physical Activity and Sport Sciences Section, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.

Physical Activity, Exercise, and Health Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain.

出版信息

Scand J Med Sci Sports. 2024 Aug;34(8):e14707. doi: 10.1111/sms.14707.

DOI:10.1111/sms.14707

PMID:39054763

Abstract

OBJECTIVE

To determine the changes in health-related quality of life (HRQoL) and sleep quality following a supervised combined exercise (EX) program compared to a Treatment-As-Usual (TAU) and to analyze the relationship between the differences in cardiorespiratory fitness (CRF) and HRQoL domains in people with schizophrenia (SZ).

METHODS

The SZ (n = 112, 41.3 ± 10.4 year) was randomly assigned into a TAU control group (n = 53) or EX-group (n = 59, 3 days/week). The 36-item Short-Form Health Survey questionnaire assessed HRQoL and the sleep quality analysis (accelerometry).

RESULTS

After the intervention (20 weeks), physical functioning (∆ = 12.9%), general health (∆ = 15.3%), mental health (∆ = 8.3%), physical component summary (PCS) (∆ = 5.1%), and sleep efficiency (∆ = 1.9%) increased (p < 0.05) in the EX, with no significant changes in the TAU for any domains studied. There were significant differences between groups whose EX showed improvements (p < 0.05) compared to TAU in physical functioning, general health, PCS, and sleep efficiency. A greater CRF was associated with better values in physical functioning, role-physical, bodily pain, general health, vitality, and PCS after the exercise program in SZ.

CONCLUSIONS

A 20-week supervised combined exercise intervention program for SZ increased sleep efficiency and physical functioning, general and mental health, and PCS scores. This could lead to a critical HRQoL change from how they were to how they should be.

TRIAL REGISTRATION

ClinicalTrials.gov identifier: NCT03509597.

摘要

目的

与常规治疗（TAU）相比，确定监督下的综合运动（EX）方案对健康相关生活质量（HRQoL）和睡眠质量的影响，并分析精神分裂症（SZ）患者心肺功能（CRF）与 HRQoL 领域之间差异的关系。

方法

将 SZ（n = 112，41.3 ± 10.4 岁）随机分配到 TAU 对照组（n = 53）或 EX 组（n = 59，每周 3 天）。使用 36 项简短健康调查问卷评估 HRQoL 和睡眠质量分析（加速度计）。

结果

干预后（20 周），EX 组的身体机能（∆ = 12.9%）、一般健康（∆ = 15.3%）、心理健康（∆ = 8.3%）、身体成分综合评分（PCS）（∆ = 5.1%）和睡眠效率（∆ = 1.9%）均有所提高（p < 0.05），而 TAU 组在任何研究领域均无显著变化。EX 组表现出改善的组间存在显著差异（p < 0.05），与 TAU 相比，EX 组在身体机能、一般健康、PCS 和睡眠效率方面表现出更好的结果。SZ 进行 20 周监督下的综合运动干预后，CRF 越高，身体机能、角色身体、身体疼痛、一般健康、活力和 PCS 的评分越高。