From discovery to replication: Power and definitions matter for multiple sclerosis severity.
作者信息
Stridh Pernilla, Huang Jesse, Kockum Ingrid
机构信息
Karolinska Neuroimmunology and Multiple Sclerosis Center, Department of Clinical Neuroscience, Karolinska Insitutet, Stockholm, Sweden.
出版信息
Mult Scler. 2024 Sep;30(10):1385-1386. doi: 10.1177/13524585241265021. Epub 2024 Jul 26.
Abstract
摘要
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No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry.在 MSBase 注册中心的 1813 名复发缓解型多发性硬化症患者中，rs10191329 严重程度位点与纵向疾病严重程度之间无关联证据。
Mult Scler. 2024 Aug;30(9):1216-1220. doi: 10.1177/13524585241240406. Epub 2024 Mar 21.
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Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real-World Cohort.多发性硬化症严重程度基因型在预测疾病进程中的相关性：一项真实世界队列研究。
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Locus for severity implicates CNS resilience in progression of multiple sclerosis.严重程度的定位提示多发性硬化进展中中枢神经系统的弹性。
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