Shao Mingyu, Liu Zhaohong, Liu Tongtong
Department of Child Health Care, Zibo Central Hospital, Zibo, Shandong, 255020, People's Republic of China.
Department of Pediatrics, Zibo Central Hospital, Zibo, Shandong, 255020, People's Republic of China.
Ther Clin Risk Manag. 2024 Jul 15;20:427-436. doi: 10.2147/TCRM.S464826. eCollection 2024.
Healthcare is essential for asthma control, however, whether family-supported healthcare improves therapeutic effects in childhood asthma remains unclear.
The enrolled patients were randomly divided into control and intervention groups. The pulmonary function was evaluated by forced expiratory volume in 1 s as a percentage of forced vital capacity (FEV1/FVC) and fractional exhaled nitric oxide (FeNO). Asthma control and life quality were assessed via a childhood asthma control test and pediatric asthma quality of life questionnaire. Inflammatory cytokines interleukin-6 (IL-6) and interleukin-17 (IL-17) were determined by enzyme-linked immunosorbent assay.
No significant differences existed in the basic characteristics of asthma children and their parents among two groups. The increase of FEV1/FVC was higher in the intervention group versus the control group (76.47 ± 10.76% vs 69.76 ± 8.88%, = 0.001 at the time of post-intervention), and the decrease of FeNO was greater in the intervention group (30.43 ± 6.85 bbp vs 35.64 ± 6.62 bbp, = 0.003 at the time of post-intervention). Family-supported healthcare highly improved asthma control and quality of life in childhood asthma post-treatment. Meanwhile, the inflammatory cytokines IL-17 (118.14 ± 25.79 pg/mL in intervention group vs 142.86 ± 28.68 pg/mL in control group, = 0.004 at the time of post-intervention) and IL-6 (103.76 ± 23.11 pg/mL in intervention group vs 119.73 ± 22.68 pg/mL in control group, = 0.009 at the time of post-intervention) significantly decreased by family-supported healthcare intervention. Importantly, acute exacerbation (80.8% in intervention group vs 95.7% in control group, = 0.030) and rehospitalization cases (88.5% in intervention group vs 100% in control group, = 0.028) also decreased by family-supported healthcare intervention.
Family-supported healthcare improves pulmonary function and quality of life while alleviates inflammation, acute exacerbation, and rehospitalization in childhood asthma post-routine treatment.
医疗保健对于哮喘控制至关重要，然而，家庭支持的医疗保健是否能提高儿童哮喘的治疗效果仍不明确。
将入选患者随机分为对照组和干预组。通过第1秒用力呼气量占用力肺活量的百分比（FEV1/FVC）和呼出一氧化氮分数（FeNO）评估肺功能。通过儿童哮喘控制测试和儿童哮喘生活质量问卷评估哮喘控制情况和生活质量。采用酶联免疫吸附测定法测定炎性细胞因子白细胞介素-6（IL-6）和白细胞介素-17（IL-17）。
两组哮喘儿童及其父母的基本特征无显著差异。干预组FEV1/FVC的升高高于对照组（干预后为76.47±10.76%对69.76±8.88%，P=0.001），干预组FeNO的降低幅度更大（干预后为30.43±6.85 ppb对35.64±6.62 ppb，P=0.003）。家庭支持的医疗保健在治疗后显著改善了儿童哮喘的控制情况和生活质量。同时，家庭支持的医疗保健干预使炎性细胞因子IL-17（干预组为118.14±25.79 pg/mL，对照组为142.86±28.68 pg/mL，干预后P=0.004）和IL-6（干预组为103.76±23.11 pg/mL，对照组为119.73±22.68 pg/mL，干预后P=0.009）显著降低。重要的是，家庭支持的医疗保健干预还降低了急性加重（干预组为80.8%，对照组为95.7%，P=0.030）和再次住院病例（干预组为88.5%，对照组为100%，P=0.028）。
家庭支持的医疗保健在常规治疗后可改善儿童哮喘的肺功能和生活质量，同时减轻炎症、急性加重和再次住院情况。
